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MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle

The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorder...

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Bibliographic Details
Published in:Scientific reports 2016-09, Vol.6 (1), p.32823-32823, Article 32823
Main Authors: del Rosario, Ricardo C. H., Damasco, Joseph Ray Clarence G., Aguda, Baltazar D.
Format: Article
Language:English
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Summary:The restriction point marks a switch in G1 from growth factor-dependent to growth factor-independent progression of the cell cycle. The proper regulation of this switch is important for normal cell processes; aberrations could result in a number of diseases such as cancer, neurodegenerative disorders, stroke and myocardial infarction. To further understand the regulation of the restriction point, we extended a mathematical model of the Rb-E2F pathway to include members of the microRNA cluster miR-17-92. Our mathematical analysis shows that microRNAs play an essential role in fine-tuning and providing robustness to the switch. We also demonstrate how microRNA regulation can steer cells in or out of cancer states.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep32823