Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy

Abstract Study Objectives: Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2016-10, Vol.39 (10), p.1811-1814
Main Authors: Hidalgo, Hildegard, Kallweit, Ulf, Mathis, Johannes, Bassetti, Claudio L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Cataplexy - diagnosis
Cataplexy - etiology
Cataplexy - genetics
Child
Databases, Factual
Encephalitis
Encephalitis Viruses, Tick-Borne - genetics
Encephalitis, Tick-Borne - epidemiology
Encephalitis, Tick-Borne - genetics
Encephalitis, Tick-Borne - prevention & control
Female
Genetic Predisposition to Disease - genetics
Germany
Humans
Influenza Vaccines - adverse effects
Male
Narcolepsy - diagnosis
Narcolepsy - etiology
Narcolepsy - genetics
Neurological Disorders
Retrospective Studies
Risk Factors
Sleep disorders
Vaccination - adverse effects
Vaccines
Young Adult
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Summary:Abstract Study Objectives: Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy. Methods: Case series and retrospective database study. Results: We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany. Conclusions: Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.
ISSN:0161-8105
1550-9109
DOI:10.5665/sleep.6160