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Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy
Abstract Study Objectives: Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at...
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| Published in: | Sleep (New York, N.Y.) N.Y.), 2016-10, Vol.39 (10), p.1811-1814 |
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| container_end_page | 1814 |
| container_issue | 10 |
| container_start_page | 1811 |
| container_title | Sleep (New York, N.Y.) |
| container_volume | 39 |
| creator | Hidalgo, Hildegard Kallweit, Ulf Mathis, Johannes Bassetti, Claudio L. |
| description | Abstract
Study Objectives:
Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy.
Methods:
Case series and retrospective database study.
Results:
We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany.
Conclusions:
Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease. |
| doi_str_mv | 10.5665/sleep.6160 |
| format | article |
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Study Objectives:
Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy.
Methods:
Case series and retrospective database study.
Results:
We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany.
Conclusions:
Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.5665/sleep.6160</identifier><identifier>PMID: 27397572</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Cataplexy - diagnosis ; Cataplexy - etiology ; Cataplexy - genetics ; Child ; Databases, Factual ; Encephalitis ; Encephalitis Viruses, Tick-Borne - genetics ; Encephalitis, Tick-Borne - epidemiology ; Encephalitis, Tick-Borne - genetics ; Encephalitis, Tick-Borne - prevention & control ; Female ; Genetic Predisposition to Disease - genetics ; Germany ; Humans ; Influenza Vaccines - adverse effects ; Male ; Narcolepsy - diagnosis ; Narcolepsy - etiology ; Narcolepsy - genetics ; Neurological Disorders ; Retrospective Studies ; Risk Factors ; Sleep disorders ; Vaccination - adverse effects ; Vaccines ; Young Adult</subject><ispartof>Sleep (New York, N.Y.), 2016-10, Vol.39 (10), p.1811-1814</ispartof><rights>2016 Associated Professional Sleep Societies, LLC.</rights><rights>Copyright © Sleep Research Society</rights><rights>2016 Associated Professional Sleep Societies, LLC. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-cd3ff1f9086ff1ca805316b1eae89a8c330f031cc914688c016d741be666c6b23</citedby><cites>FETCH-LOGICAL-c436t-cd3ff1f9086ff1ca805316b1eae89a8c330f031cc914688c016d741be666c6b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27397572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hidalgo, Hildegard</creatorcontrib><creatorcontrib>Kallweit, Ulf</creatorcontrib><creatorcontrib>Mathis, Johannes</creatorcontrib><creatorcontrib>Bassetti, Claudio L.</creatorcontrib><title>Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy</title><title>Sleep (New York, N.Y.)</title><addtitle>Sleep</addtitle><description>Abstract
Study Objectives:
Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy.
Methods:
Case series and retrospective database study.
Results:
We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany.
Conclusions:
Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cataplexy - diagnosis</subject><subject>Cataplexy - etiology</subject><subject>Cataplexy - genetics</subject><subject>Child</subject><subject>Databases, Factual</subject><subject>Encephalitis</subject><subject>Encephalitis Viruses, Tick-Borne - genetics</subject><subject>Encephalitis, Tick-Borne - epidemiology</subject><subject>Encephalitis, Tick-Borne - genetics</subject><subject>Encephalitis, Tick-Borne - prevention & control</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Germany</subject><subject>Humans</subject><subject>Influenza Vaccines - adverse effects</subject><subject>Male</subject><subject>Narcolepsy - diagnosis</subject><subject>Narcolepsy - etiology</subject><subject>Narcolepsy - genetics</subject><subject>Neurological Disorders</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sleep disorders</subject><subject>Vaccination - adverse effects</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kVFLwzAUhYMobk5f_AFSEEGEam7TpsmLoGM6YagP6mvIstRFu6Ymrbp_b-amqA--3MPlfhzO5SC0C_g4ozQ78aXW9TEFitdQF7IMxxwwX0ddDBRiBjjroC3vn3DYU042USfJCc-zPOmi4a31TXRn1HN8bl2lo0GldD2VpWmMjx6Ma8OUSplKNsZW0bV0ypa69vPozTTTqC8bWZf6fb6NNgpZer2z0h66vxjc9Yfx6Obyqn82ilVKaBOrCSkKKDhmNKiSDGcE6Bi01IxLpgjBBSagFIeUMqZC5EmewlhTShUdJ6SHTpe-dTue6YnSVeNkKWpnZtLNhZVG_L5UZioe7avIcIIJJcHgcGXg7EurfSNmxitdlrLStvUCWEJzSHOWB3T_D_pkW1eF9wRwyjkHDixQR0tKOeu908V3GMBiUZD4LEgsCgrw3s_43-hXIwE4WAK2rf8z-gAdl5lT</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Hidalgo, Hildegard</creator><creator>Kallweit, Ulf</creator><creator>Mathis, Johannes</creator><creator>Bassetti, Claudio L.</creator><general>Oxford University Press</general><general>Associated Professional Sleep Societies, LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy</title><author>Hidalgo, Hildegard ; Kallweit, Ulf ; Mathis, Johannes ; Bassetti, Claudio L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-cd3ff1f9086ff1ca805316b1eae89a8c330f031cc914688c016d741be666c6b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cataplexy - diagnosis</topic><topic>Cataplexy - etiology</topic><topic>Cataplexy - genetics</topic><topic>Child</topic><topic>Databases, Factual</topic><topic>Encephalitis</topic><topic>Encephalitis Viruses, Tick-Borne - genetics</topic><topic>Encephalitis, Tick-Borne - epidemiology</topic><topic>Encephalitis, Tick-Borne - genetics</topic><topic>Encephalitis, Tick-Borne - prevention & control</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Germany</topic><topic>Humans</topic><topic>Influenza Vaccines - adverse effects</topic><topic>Male</topic><topic>Narcolepsy - diagnosis</topic><topic>Narcolepsy - etiology</topic><topic>Narcolepsy - genetics</topic><topic>Neurological Disorders</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sleep disorders</topic><topic>Vaccination - adverse effects</topic><topic>Vaccines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hidalgo, Hildegard</creatorcontrib><creatorcontrib>Kallweit, Ulf</creatorcontrib><creatorcontrib>Mathis, Johannes</creatorcontrib><creatorcontrib>Bassetti, Claudio L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hidalgo, Hildegard</au><au>Kallweit, Ulf</au><au>Mathis, Johannes</au><au>Bassetti, Claudio L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><addtitle>Sleep</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>39</volume><issue>10</issue><spage>1811</spage><epage>1814</epage><pages>1811-1814</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Study Objectives:
Narcolepsy with cataplexy (NC) is a chronic neurological disorder thought to result from an altered immune response based on a genetic predisposition coupled with environmental factors. Pandemrix vaccination has been reported to increase the risk of narcolepsy. We aimed at identifying other vaccines associated with the onset of narcolepsy.
Methods:
Case series and retrospective database study.
Results:
We identified four cases of NC following a tick-borne encephalitis (TBE) vaccination with FSME Immun. Additional four cases could be detected in the database of the Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines in Germany.
Conclusions:
Our findings implicate TBE vaccination as a potential additional environmental factor for the development of NC and add additional evidence for an immunological mechanism in the pathogenesis of the disease.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>27397572</pmid><doi>10.5665/sleep.6160</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0161-8105 |
| ispartof | Sleep (New York, N.Y.), 2016-10, Vol.39 (10), p.1811-1814 |
| issn | 0161-8105 1550-9109 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5020363 |
| source | Oxford Journals Online; Alma/SFX Local Collection |
| subjects | Adolescent Adult Cataplexy - diagnosis Cataplexy - etiology Cataplexy - genetics Child Databases, Factual Encephalitis Encephalitis Viruses, Tick-Borne - genetics Encephalitis, Tick-Borne - epidemiology Encephalitis, Tick-Borne - genetics Encephalitis, Tick-Borne - prevention & control Female Genetic Predisposition to Disease - genetics Germany Humans Influenza Vaccines - adverse effects Male Narcolepsy - diagnosis Narcolepsy - etiology Narcolepsy - genetics Neurological Disorders Retrospective Studies Risk Factors Sleep disorders Vaccination - adverse effects Vaccines Young Adult |
| title | Post Tick-Borne Encephalitis Virus Vaccination Narcolepsy with Cataplexy |
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