Long-term effects of adenotonsillectomy in children with obstructive sleep apnoea: protocol for a systematic review

IntroductionAdenotonsillar hypertrophy is the most important anatomical factor associated with obstructive sleep apnoea syndrome in children. The American Academy of Pediatrics recommends adenotonsillectomy as the first line of treatment. AT can reduce the apnoea hypopnoea index; however, its effect...

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Bibliographic Details
Published in:BMJ open 2016-09, Vol.6 (9), p.e010030-e010030
Main Authors: Damiani, Felipe, Rada, Gabriel, Gana, Juan Cristóbal, Brockmann, Pablo E, Alberti, Gigliola
Format: Article
Language:English
Subjects:
Adenoidectomy
Adenoids - pathology
Adenoids - surgery
Child
Humans
Hypertrophy
Paediatrics
Palatine Tonsil - pathology
Palatine Tonsil - surgery
Research Design
Sleep Apnea, Obstructive - surgery
Systematic review
Systematic Reviews as Topic
Tonsillectomy
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Summary:IntroductionAdenotonsillar hypertrophy is the most important anatomical factor associated with obstructive sleep apnoea syndrome in children. The American Academy of Pediatrics recommends adenotonsillectomy as the first line of treatment. AT can reduce the apnoea hypopnoea index; however, its effect on long-term outcomes remains unclear.Methods and analysisWe will conduct an electronic search for randomised controlled trials in MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL) and EMBASE. We will also identify literature by reviewing the references included in the selected studies and relevant reviews, screening through important scientific conferences, and searching for ongoing trials in the WHO International Clinical Trials Registry Platform. Two researchers will independently undertake selection of studies, data extraction and assessment of the risk of bias of included studies. We will estimate pooled risk ratios for dichotomous data, and mean difference or standardised mean difference for continuous outcomes. A random-effects model will be used for meta-analyses. Data synthesis and other analyses will be conducted using RevMan V.5.3 software.Ethics and disseminationNo ethics approval is considered necessary. The results of this study will be disseminated via peer-reviewed publications and social networks.Trial registration numberCRD42015022102.
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-010030