Subsequent risk of ipsilateral and contralateral invasive breast cancer after treatment for ductal carcinoma in situ: incidence and the effect of radiotherapy in a population-based cohort of 10,090 women

Purpose To assess the effect of different treatment strategies on the risk of subsequent invasive breast cancer (IBC) in women diagnosed with ductal carcinoma in situ (DCIS). Methods Up to 15-year cumulative incidences of ipsilateral IBC (iIBC) and contralateral IBC (cIBC) were assessed among a popu...

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Bibliographic Details
Published in:Breast cancer research and treatment 2016-10, Vol.159 (3), p.553-563
Main Authors: Elshof, Lotte E., Schaapveld, Michael, Schmidt, Marjanka K., Rutgers, Emiel J., van Leeuwen, Flora E., Wesseling, Jelle
Format: Article
Language:English
Subjects:
Aged
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Cancer research
Cancer therapies
Cancer treatment
Carcinoma
Carcinoma, Ductal, Breast - epidemiology
Carcinoma, Intraductal, Noninfiltrating - radiotherapy
Carcinoma, Intraductal, Noninfiltrating - surgery
Cohort Studies
College football
Disease-Free Survival
Drug therapy
Epidemiology
Female
Health aspects
Humans
Incidence
Mastectomy - adverse effects
Mastectomy - methods
Mastectomy, Segmental - adverse effects
Mastectomy, Segmental - methods
Medicine
Medicine & Public Health
Middle Aged
Multimodal Imaging
Netherlands - epidemiology
Oncology
Proportional Hazards Models
Radiation therapy
Radiotherapy
Risk factors
Treatment Outcome
Women
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Summary:Purpose To assess the effect of different treatment strategies on the risk of subsequent invasive breast cancer (IBC) in women diagnosed with ductal carcinoma in situ (DCIS). Methods Up to 15-year cumulative incidences of ipsilateral IBC (iIBC) and contralateral IBC (cIBC) were assessed among a population-based cohort of 10,090 women treated for DCIS in the Netherlands between 1989 and 2004. Multivariable Cox regression analyses were used to evaluate associations of treatment with iIBC risk. Results Fifteen years after DCIS diagnosis, cumulative incidence of iIBC was 1.9 % after mastectomy, 8.8 % after BCS+RT, and 15.4 % after BCS alone. Patients treated with BCS alone had a higher iIBC risk than those treated with BCS+RT during the first 5 years after treatment. This difference was less pronounced for patients 
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-016-3973-y