Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study

AIMS--To study the expression of a range of cytokeratins by malignant myoepithelioma of the breast. METHODS--Immunophenotyping was carried out using a panel of antibodies on paraffin wax embedded and frozen material using immunohistochemistry and double-labelled immunofluorescence. Electron microsco...

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Bibliographic Details
Published in:Journal of clinical pathology 1995-02, Vol.48 (2), p.164-167
Main Authors: Lakhani, S R, O'Hare, M J, Monaghan, P, Winehouse, J, Gazet, J C, Sloane, J P
Format: Article
Language:English
Subjects:
Actins - analysis
Aged
Biological and medical sciences
Biomarkers, Tumor - analysis
Breast Neoplasms - chemistry
Breast Neoplasms - ultrastructure
Carcinoma - chemistry
Carcinoma - ultrastructure
Cell Adhesion Molecules - analysis
Female
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Immunophenotyping
Keratins - analysis
Mammary gland diseases
Medical sciences
Microscopy, Electron
Tumors
Vimentin - analysis
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Summary:AIMS--To study the expression of a range of cytokeratins by malignant myoepithelioma of the breast. METHODS--Immunophenotyping was carried out using a panel of antibodies on paraffin wax embedded and frozen material using immunohistochemistry and double-labelled immunofluorescence. Electron microscopy was also performed. RESULTS--The tumour cells were positive for CAM 5.2, actin, vimentin, and cytokeratin 14 and negative for cytokeratins 18 and 19. Electron microscopy showed well formed desmosomes and hemidesmosomes together with pinocytic vesicles, plentiful rough endoplasmic reticulum and 6 nM microfilaments with focal densities. CONCLUSIONS--The pattern of cytokeratin expression provides further evidence that tumours with a specific myoepithelial phenotype occur rarely in the breast.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.48.2.164