Association between serum vitamin D levels and gastric cancer:A retrospective chart analysis

• Published in: World journal of gastrointestinal oncology 2016-09, Vol.8 (9), p.688-694
• Main Authors: Vyas, Neil, Companioni, Rafael Ching, Tiba, Melik, Alkhawam, Hassan, Catalano, Carmine, Sogomonian, Robert, Baum, Joel, Walfish, Aaron
• Format: Article
• Language: English
• Subjects: cancer; Adenocarcinoma; Vitamin; Gastric; Retrospective Cohort Study
• ISSN: 1948-5204; 1948-5204
• DOI: 10.4251/wjgo.v8.i9.688

AIM To determine whether there is an increased risk of gastric adenocarcinoma associated with vitamin D deficiency(VDd).METHODS A retrospective case control study was performed of all patients diagnosed with gastric adenocarcinoma between 2005 and 2015.After we excluded the patients without a documented vitamin D level,49 patients were included in our study.RESULTS The average age of patients with gastric adenocarcinoma and documented vitamin D level was 64 years old(95%CI: 27-86) and average vitamin D level was 20.8 mg/d L(95%CI: 4-44).Compared to a matched control group,the prevalence of VDd/insufficiency in patients with gastric adenocarcinoma was significantly higher than normal vitamin D levels(83.7% vs 16.3%).Forty-one patients(83.7%) with adenocarcinoma showed VDd/insufficiency compared to 18(37%) patients with normal vitamin D level without gastric cancer(OR: 8.8,95%CI: 5-22,P value < 0.0001).The average age of males with gastric adenocarcinoma diagnosis was 60 years old vs 68 years old for females(P = 0.01).StageⅡ gastric adenocarcinoma was the most prevalent in our study(37%).CONCLUSION We reported a positive relationship between VDd and gastric adenocarcinoma,that is to say,patients with decreased VDd levels have an increased propensity for gastric adenocarcinoma.