IL-6, IL-10 and TNFα do not improve early detection of post-endoscopic retrograde cholangiopancreatography acute pancreatitis: a prospective cohort study

The most reliable indicators for post-ERCP acute pancreatitis are elevated amylase levels and abdominal pain 24 hours after ERCP. As ERCP is often performed on an outpatient basis, earlier diagnosis is important. We aimed to identify early predictors of post-ERCP pancreatitis. We prospectively analy...

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Bibliographic Details
Published in:Scientific reports 2016-09, Vol.6 (1), p.33492-33492, Article 33492
Main Authors: Concepción-Martín, Mar, Gómez-Oliva, Cristina, Juanes, Ana, Mora, Josefina, Vidal, Silvia, Díez, Xavier, Torras, Xavier, Sainz, Sergio, Villanueva, Candid, Farré, Antoni, Guarner-Argente, Carlos, Guarner, Carlos
Format: Article
Language:English
Subjects:
631/92
692/4020/1503/1712/1714
Abdominal Pain - etiology
Aged
Amylases - blood
Cholangiopancreatography, Endoscopic Retrograde - adverse effects
Demography
Early Diagnosis
Female
Humanities and Social Sciences
Humans
Interleukin-10 - blood
Interleukin-6 - blood
Lipase - blood
Male
multidisciplinary
Pancreatitis - blood
Pancreatitis - diagnosis
Pancreatitis - etiology
Predictive Value of Tests
Prospective Studies
ROC Curve
Science
Sensitivity and Specificity
Severity of Illness Index
Tumor Necrosis Factor-alpha - blood
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Summary:The most reliable indicators for post-ERCP acute pancreatitis are elevated amylase levels and abdominal pain 24 hours after ERCP. As ERCP is often performed on an outpatient basis, earlier diagnosis is important. We aimed to identify early predictors of post-ERCP pancreatitis. We prospectively analyzed IL-6, IL-10, TNFα, CRP, amylase and lipase before and 4 hours after ERCP, and studied their association with abdominal pain. We included 510 patients. Post-ERCP pancreatitis occurred in 36 patients (7.1%). IL-6, IL-10, TNFα and CRP were not associated with post-ERCP pancreatitis. Levels of amylase and lipase were higher in patients with pancreatitis (522 U/L and 1808 U/L vs. 78 U/L and 61 U/L, respectively; p  3 ULN. Amylase and lipase were the only markers of post-ERCP pancreatitis 4 hours after the procedure.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep33492