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Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study
Background The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features. Objective We sought to determine trends in diagnosis and clinical features of MIS. Methods Incident cases of melanoma were collected prospectively from the Nurses'...
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| Published in: | Journal of the American Academy of Dermatology 2016-10, Vol.75 (4), p.698-705 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Wei, Erin X., MD Qureshi, Abrar A., MD, MPH Han, Jiali, PhD Li, Tricia Y., MD, MS Cho, Eunyoung, ScD Lin, Jennifer Y., MD Li, Wen-Qing, PhD |
| description | Background The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features. Objective We sought to determine trends in diagnosis and clinical features of MIS. Methods Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Results MIS incidence increased from 2 to 42 per 100,000 person-year among women, and from 11 to 73 per 100,000 person-year among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on the upper half of the body ( P |
| doi_str_mv | 10.1016/j.jaad.2016.05.011 |
| format | article |
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Objective We sought to determine trends in diagnosis and clinical features of MIS. Methods Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Results MIS incidence increased from 2 to 42 per 100,000 person-year among women, and from 11 to 73 per 100,000 person-year among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on the upper half of the body ( P < .001). Invasive melanomas were diagnosed at a younger age than MIS ( P < .001), and were more likely to be found on the lower extremities than MIS ( P < .001). Limitations This is a strictly descriptive study without examination into mechanisms. Conclusion We found epidemiologic and clinical differences for in situ and invasive melanomas, which support further examination into the variations in etiologic pathways. The lack of improvement in mortality despite the increase in detection of in situ relative to invasive lesions further highlights the need to improve invasive melanoma-specific clinical screening features.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2016.05.011</identifier><identifier>PMID: 27436155</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; age ; Age Distribution ; Aged ; anatomic sites ; Carcinoma in Situ - diagnosis ; Carcinoma in Situ - epidemiology ; Carcinoma in Situ - pathology ; Dermatology ; epidemiology ; Female ; gender ; Humans ; Hutchinson's Melanotic Freckle - epidemiology ; Hutchinson's Melanotic Freckle - pathology ; Incidence ; invasive malignant melanoma ; lentigo maligna ; Male ; melanoma ; Melanoma - diagnosis ; Melanoma - epidemiology ; Melanoma - pathology ; melanoma in situ ; melanoma screening ; Melanoma, Cutaneous Malignant ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; occupational cohorts ; Prospective Studies ; Risk Assessment ; Sex Distribution ; Skin Neoplasms - diagnosis ; Skin Neoplasms - epidemiology ; Skin Neoplasms - pathology ; United States - epidemiology</subject><ispartof>Journal of the American Academy of Dermatology, 2016-10, Vol.75 (4), p.698-705</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2016 American Academy of Dermatology, Inc.</rights><rights>Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-fc4ab38fe7744cce6b271ffc30f7af6dcc34f104a9954c2fb056b406e205d9893</citedby><cites>FETCH-LOGICAL-c510t-fc4ab38fe7744cce6b271ffc30f7af6dcc34f104a9954c2fb056b406e205d9893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27436155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Erin X., MD</creatorcontrib><creatorcontrib>Qureshi, Abrar A., MD, MPH</creatorcontrib><creatorcontrib>Han, Jiali, PhD</creatorcontrib><creatorcontrib>Li, Tricia Y., MD, MS</creatorcontrib><creatorcontrib>Cho, Eunyoung, ScD</creatorcontrib><creatorcontrib>Lin, Jennifer Y., MD</creatorcontrib><creatorcontrib>Li, Wen-Qing, PhD</creatorcontrib><title>Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features. Objective We sought to determine trends in diagnosis and clinical features of MIS. Methods Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Results MIS incidence increased from 2 to 42 per 100,000 person-year among women, and from 11 to 73 per 100,000 person-year among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on the upper half of the body ( P < .001). Invasive melanomas were diagnosed at a younger age than MIS ( P < .001), and were more likely to be found on the lower extremities than MIS ( P < .001). Limitations This is a strictly descriptive study without examination into mechanisms. Conclusion We found epidemiologic and clinical differences for in situ and invasive melanomas, which support further examination into the variations in etiologic pathways. The lack of improvement in mortality despite the increase in detection of in situ relative to invasive lesions further highlights the need to improve invasive melanoma-specific clinical screening features.</description><subject>Adult</subject><subject>age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>anatomic sites</subject><subject>Carcinoma in Situ - diagnosis</subject><subject>Carcinoma in Situ - epidemiology</subject><subject>Carcinoma in Situ - pathology</subject><subject>Dermatology</subject><subject>epidemiology</subject><subject>Female</subject><subject>gender</subject><subject>Humans</subject><subject>Hutchinson's Melanotic Freckle - epidemiology</subject><subject>Hutchinson's Melanotic Freckle - pathology</subject><subject>Incidence</subject><subject>invasive malignant melanoma</subject><subject>lentigo maligna</subject><subject>Male</subject><subject>melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - epidemiology</subject><subject>Melanoma - pathology</subject><subject>melanoma in situ</subject><subject>melanoma screening</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>occupational cohorts</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Distribution</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - pathology</subject><subject>United States - epidemiology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9Uk1v1DAQtRCILoU_wAH5WCQSxo7zhVClquKjUhGHbc-W44xbh6y92MmiPfHXcdi2Ag6cPNa89-x5bwh5ySBnwKq3Qz4o1ec81TmUOTD2iKwYtHVW1U39mKyAtZC1FedH5FmMAwC0oqifkiNei6JiZbkiP68Cuj5S6-h0i7S36sb5aCNVrqd6tM5qNVKDapoDRuoN3eConN-ohRLtNNOTLxfr18vtep2a7jfzh0_VO3pGt8HHLerJ7vAN9V3EsFOT9S6Jxmnu98_JE6PGiC_uzmNy_fHD1fnn7PLrp4vzs8tMlwymzGihuqIxWNdCaI1Vx2tmjC7A1MpUvdaFMAyEattSaG46KKtOQIUcyr5t2uKYnB50t3O3wV6jm4Ia5TbYjQp76ZWVf3ecvZU3fidLKJK_TRI4uRMI_vuMcZIbGzWOyQz0c5Ss4ZyxpuYiQfkBqtPwMaB5eIaBXJKTg1ySk0tyEkqZkkukV39-8IFyH1UCvD8AMNm0sxhk1Badxt6GZLDsvf2__uk_9Pt0v-Ee4-DnkEJJc8jIJcj1sjvL6rCqAN6mqX4BSWLAyQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Wei, Erin X., MD</creator><creator>Qureshi, Abrar A., MD, MPH</creator><creator>Han, Jiali, PhD</creator><creator>Li, Tricia Y., MD, MS</creator><creator>Cho, Eunyoung, ScD</creator><creator>Lin, Jennifer Y., MD</creator><creator>Li, Wen-Qing, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study</title><author>Wei, Erin X., MD ; Qureshi, Abrar A., MD, MPH ; Han, Jiali, PhD ; Li, Tricia Y., MD, MS ; Cho, Eunyoung, ScD ; Lin, Jennifer Y., MD ; Li, Wen-Qing, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-fc4ab38fe7744cce6b271ffc30f7af6dcc34f104a9954c2fb056b406e205d9893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>age</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>anatomic sites</topic><topic>Carcinoma in Situ - diagnosis</topic><topic>Carcinoma in Situ - epidemiology</topic><topic>Carcinoma in Situ - pathology</topic><topic>Dermatology</topic><topic>epidemiology</topic><topic>Female</topic><topic>gender</topic><topic>Humans</topic><topic>Hutchinson's Melanotic Freckle - epidemiology</topic><topic>Hutchinson's Melanotic Freckle - pathology</topic><topic>Incidence</topic><topic>invasive malignant melanoma</topic><topic>lentigo maligna</topic><topic>Male</topic><topic>melanoma</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - epidemiology</topic><topic>Melanoma - pathology</topic><topic>melanoma in situ</topic><topic>melanoma screening</topic><topic>Melanoma, Cutaneous Malignant</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>occupational cohorts</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Distribution</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - pathology</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Erin X., MD</creatorcontrib><creatorcontrib>Qureshi, Abrar A., MD, MPH</creatorcontrib><creatorcontrib>Han, Jiali, PhD</creatorcontrib><creatorcontrib>Li, Tricia Y., MD, MS</creatorcontrib><creatorcontrib>Cho, Eunyoung, ScD</creatorcontrib><creatorcontrib>Lin, Jennifer Y., MD</creatorcontrib><creatorcontrib>Li, Wen-Qing, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Erin X., MD</au><au>Qureshi, Abrar A., MD, MPH</au><au>Han, Jiali, PhD</au><au>Li, Tricia Y., MD, MS</au><au>Cho, Eunyoung, ScD</au><au>Lin, Jennifer Y., MD</au><au>Li, Wen-Qing, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>75</volume><issue>4</issue><spage>698</spage><epage>705</epage><pages>698-705</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><abstract>Background The incidence of melanoma in situ (MIS) is increasing, but little is known about its clinical and epidemiologic features. Objective We sought to determine trends in diagnosis and clinical features of MIS. Methods Incident cases of melanoma were collected prospectively from the Nurses' Health Study (1976-2010) and Health Professionals Follow-up Study (1986-2010). Results MIS incidence increased from 2 to 42 per 100,000 person-year among women, and from 11 to 73 per 100,000 person-year among men, exceeding the rate of increase of invasive melanomas. Melanoma mortality initially increased during the follow-up period then plateaued. Men were more likely than women to develop in situ melanomas on the upper half of the body ( P < .001). Invasive melanomas were diagnosed at a younger age than MIS ( P < .001), and were more likely to be found on the lower extremities than MIS ( P < .001). Limitations This is a strictly descriptive study without examination into mechanisms. Conclusion We found epidemiologic and clinical differences for in situ and invasive melanomas, which support further examination into the variations in etiologic pathways. The lack of improvement in mortality despite the increase in detection of in situ relative to invasive lesions further highlights the need to improve invasive melanoma-specific clinical screening features.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27436155</pmid><doi>10.1016/j.jaad.2016.05.011</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult age Age Distribution Aged anatomic sites Carcinoma in Situ - diagnosis Carcinoma in Situ - epidemiology Carcinoma in Situ - pathology Dermatology epidemiology Female gender Humans Hutchinson's Melanotic Freckle - epidemiology Hutchinson's Melanotic Freckle - pathology Incidence invasive malignant melanoma lentigo maligna Male melanoma Melanoma - diagnosis Melanoma - epidemiology Melanoma - pathology melanoma in situ melanoma screening Melanoma, Cutaneous Malignant Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging occupational cohorts Prospective Studies Risk Assessment Sex Distribution Skin Neoplasms - diagnosis Skin Neoplasms - epidemiology Skin Neoplasms - pathology United States - epidemiology |
| title | Trends in the diagnosis and clinical features of melanoma in situ (MIS) in US men and women: A prospective, observational study |
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