Diagnostic Approach to Patients with Atypical Squamous Cells of Undetermined Significance Cytologic Findings on Cervix

• Published in: Medicinski arhiv 2016-07, Vol.70 (4), p.296-298
• Main Authors: Jahic, Mahira, Jahic, Elmir
• Format: Article
• Language: English
• Subjects: Adult; Atypical Squamous Cells of the Cervix - pathology; Atypical Squamous Cells of the Cervix - virology; Female; Humans; Middle Aged; Original Paper; Papanicolaou Test; Papillomavirus Infections - complications; Papillomavirus Infections - pathology; Prospective Studies; Vaginal Smears
• ISSN: 0350-199X; 1986-5961
• DOI: 10.5455/medarh.2016.70.296-298

Atypical squamous cells of undetermined significance (ASCUS) is a term that refers to inflammatory, reactive and reparative processes which are atypical and of higher level and insufficient to be classified as cervical intraepithelial lesions (CIN). Examine of frequency of HPV infection in ASCUS lesions and regression, stagnation and progression during six-month period. Prospective study was conducted over a period of 3 years. In private gynecological ambulance "Dr Mahira Jahic". Analysis of PAP smears and HPV typization have been done in 50 patients and PAP test has been repeated after six months. X² test was used for statistical analysis. Analysis of 1784 PAP smears showed normal results in 86,6% (N-1530), and abnormal in 13% (N-254). ASCUS in 7,4% (N-133) and ASC-H in 0,5% (N-9), LSIL in 4,4% (N-80), HSIL in 1,3% (N-24), CIN II in 1,2% (N-20), CIN III in 0,2% (N-4). Progression occurred in 18% (9), persistence in 74% (37) and regression in 8%. Patients with ASC-H lesion 0,5% (N-9), PH results showed 22% (N-2) Carcinoma in situ, 33% (N-3) CIN II, 22% (N-2) CIN I and 22% (N-2) chronic cervicitis. Patients with CIN I in 88% (N-7) were positive on HPV of high risk. Patients with persistent ASCUS result were positive in 51% (N-19). The number of CIN I lesions found in women with ASCUS is bigger and statistically significant (p