Malnutrition Is Associated with Protection from Rotavirus Diarrhea: Evidence from a Longitudinal Birth Cohort Study in Bangladesh

Rotavirus is a leading cause of dehydrating diarrhea and death among infants and children globally, particularly in communities of the developing world. While numerous studies have described the complex relationships among infectious diarrhea, growth faltering, and poverty, the impact of nutritional...

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Published in:Journal of clinical microbiology 2016-10, Vol.54 (10), p.2568-2574
Main Authors: Verkerke, Hans, Sobuz, Shihab, Ma, Jennie Z, Petri, Sarah E, Reichman, Dan, Qadri, Firdausi, Rahman, Mustafizur, Haque, Rashidul, Petri, Jr, William A
Format: Article
Language:English
Subjects:
Adult
Bangladesh - epidemiology
Child Development
Child, Preschool
Diarrhea - epidemiology
Diarrhea - immunology
Disease Resistance
Female
Humans
Incidence
Infant
Infant, Newborn
Longitudinal Studies
Male
Malnutrition - complications
Pregnancy
Reoviridae
Rotavirus Infections - epidemiology
Rotavirus Infections - immunology
Virology
Young Adult
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Summary:Rotavirus is a leading cause of dehydrating diarrhea and death among infants and children globally, particularly in communities of the developing world. While numerous studies have described the complex relationships among infectious diarrhea, growth faltering, and poverty, the impact of nutritional status on susceptibility to rotavirus diarrhea is not well understood. In a longitudinal study conducted over the first 3 years of life among 626 slum-dwelling infants enrolled at birth in Dhaka, Bangladesh, we observed that common measures of healthy growth and development were positively associated with a risk of symptomatic rotavirus infection. This finding runs counter to the idea that improving childhood nutrition will implicitly decrease the incidence of symptomatic infection by enteric pathogens. As childhood nutrition improves worldwide, rotavirus infection may remain a public health challenge, making universal vaccination of even greater importance.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.00916-16