Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples tha...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2016-10, Vol.60 (10), p.6356-6358
Main Authors: Delgado-Blas, Jose F, Ovejero, Cristina M, Abadia-Patiño, Lorena, Gonzalez-Zorn, Bruno
Format: Article
Language:English
Subjects:
Animals
beta-Lactamases
beta-Lactamases - genetics
Colistin - pharmacology
Dogs
Drug Resistance, Multiple, Bacterial - drug effects
Drug Resistance, Multiple, Bacterial - genetics
Enterobacteriaceae
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Proteins
Escherichia coli Proteins - genetics
Feces - microbiology
Humans
Mechanisms of Resistance
Microbial Sensitivity Tests
Poultry
Swine
Venezuela
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Summary:We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01319-16