Expression and prognostic significance of CTBP2 in human gliomas

Deregulated expression of C-terminal-binding protein 2 (CTBP2) has been observed previously in a number of tumors, such as hepatocellular carcinoma and prostatic cancer, in the colorectal cancer SW480 cell line and in the human embryonic kidney 293 cell line. In the present study, western blot analy...

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Bibliographic Details
Published in:Oncology letters 2016-10, Vol.12 (4), p.2429-2434
Main Authors: Wang, Yong, Che, Shusheng, Cai, Gang, He, Yuchao, Chen, Jialei, Xu, Wei
Format: Article
Language:English
Subjects:
Binding proteins
Biotechnology
Brain cancer
Cancer therapies
Care and treatment
Cell cycle
Cell growth
Chemotherapy
Clinical significance
CTBP2
Development and progression
Disease
expression
Gene expression
Genetic aspects
Glioma
Gliomas
Health aspects
Medical prognosis
Patients
Prostate cancer
Proteins
Radiation therapy
Studies
Tumorigenesis
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Summary:Deregulated expression of C-terminal-binding protein 2 (CTBP2) has been observed previously in a number of tumors, such as hepatocellular carcinoma and prostatic cancer, in the colorectal cancer SW480 cell line and in the human embryonic kidney 293 cell line. In the present study, western blot analysis and immunohistochemistry were performed to investigate whether gliomas exhibit deregulated CTBP2 expression. Kaplan-Meier survival analyses were performed to evaluate the associations between CTBP2 expression, clinicopathological data and patient survival in glioma patients. The results revealed that CTBP2 expression was significantly upregulated in high grade glioma tissues compared with that in low grade glioma and normal brain tissues. Furthermore, increased CTBP2 expression in gliomas was significantly associated with a higher World Health Organization (WHO) tumor grade (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4998