Clinicopathological analysis of CD44 and CD24 expression in invasive breast cancer

A subpopulation of breast cancer cells with cluster of differentiation (CD)44-positive and CD24-negative expression has been reported to have stem cell properties and to have a higher tumorigenic capacity than other cells. However, the clinicopathological characteristics of this subpopulation are no...

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Bibliographic Details
Published in:Oncology letters 2016-10, Vol.12 (4), p.2728-2733
Main Authors: Jang, Min Hye, Kang, Hyun Jong, Jang, Ki Seok, Paik, Seung Sam, Kim, Wan Seop
Format: Article
Language:English
Subjects:
Antigens
Breast cancer
Cancer therapies
Care and treatment
CD44+/CD24
Cellular proteins
clinicopathological characteristics
Development and progression
Epidermal growth factor
Gene expression
Genetic aspects
Health aspects
HER2
Hybridization
Lymphatic system
Metastasis
Oncology
stem cell property
Stem cells
Tumors
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Summary:A subpopulation of breast cancer cells with cluster of differentiation (CD)44-positive and CD24-negative expression has been reported to have stem cell properties and to have a higher tumorigenic capacity than other cells. However, the clinicopathological characteristics of this subpopulation are not fully understood. In this study, we aimed to identify the correlations between the expression of CD44 and CD24 and clinicopathological parameters and overall survival. We studied specimens from 262 patients with invasive breast cancer. Immunohistochemical staining for CD44 and CD24 was performed using tissue microarrays. The clinicopathological factors were evaluated from the patients' medical records. In correlation analysis, CD44 expression was significantly associated with human epidermal growth factor receptor 2 (HER2)-negative status (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.4987