Investigation of the association between mitochondrial DNA and p53 gene mutations in transitional cell carcinoma of the bladder

Bladder carcinoma is the most common malignancy of the urinary tract. The major aim of the present study is to investigate the association between mitochondrial DNA (mtDNA) and p53 gene mutations in bladder carcinoma. A total of 30 patients with transitional cell carcinoma and 27 controls were recru...

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Bibliographic Details
Published in:Oncology letters 2016-10, Vol.12 (4), p.2872-2879
Main Authors: Avcilar, Tuba, Kirac, Deniz, Ergec, Deniz, Koc, Gulsah, Ulucan, Korkut, Kaya, Zehra, Kaspar, Elif Cigdem, Turkeri, Levent, Guney, Ahmet Ilter
Format: Article
Language:English
Subjects:
Bladder cancer
bladder carcinoma
Cell cycle
Cytochrome
Dehydrogenases
Deoxyribonucleic acid
Development and progression
DNA
DNA polymerase
Gene expression
Gene mutation
Genes
Genetic aspects
Genetic testing
Health aspects
Medical research
Mitochondrial DNA
mtDNA
Mutation
Oncology
p53
TCC
Tumors
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Summary:Bladder carcinoma is the most common malignancy of the urinary tract. The major aim of the present study is to investigate the association between mitochondrial DNA (mtDNA) and p53 gene mutations in bladder carcinoma. A total of 30 patients with transitional cell carcinoma and 27 controls were recruited for the study. Bladder cancer tissues were obtained by radical cystectomy or transurethral resection. Genomic DNA was extracted from peripheral blood. mtDNA and p53 genes were amplified by polymerase chain reaction and sequenced directly. A total of 37 polymorphisms were identified, among which, 2 mutations were significant in the patient group, and 1 mutation was significant in the control group. Additionally, 5 different moderate positive correlations between mtDNA mutations and 3 different positive correlations between p53 gene and mtDNA mutations were detected. The high incidence of mtDNA and p53 gene mutations in bladder cancer suggests that these genes could be important in carcinogenesis.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.5000