Clinical characteristics of drug-induced liver injury and related risk factors

Drug-induced liver injury (DILI) is often undiagnosed or misdiagnosed clinically because of diagnostic difficulties caused by lack of laboratory-specific serological markers. In this study, we comprehensively assessed the clinical characteristics, laboratory indices, hepatotoxic drugs, risk factors...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2016-10, Vol.12 (4), p.2606-2616
Main Authors: Lu, Ren-Jie, Zhang, Yan, Tang, Feng-Lei, Zheng, Zhong-Wei, Fan, Zheng-Da, Zhu, Shan-Mei, Qian, Xian-Feng, Liu, Na-Na
Format: Article
Language:English
Subjects:
Antigens
Autoantibodies
Care and treatment
Classification
clinical feature
Complications and side effects
Drug dosages
drug-induced liver injury
Family medical history
Hepatitis
Hypertension
Infections
Laboratories
Liver diseases
Metabolism
Metabolites
Pathogenesis
Patients
Phosphatase
risk factor
Risk factors
Thrombin
Urine
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Summary:Drug-induced liver injury (DILI) is often undiagnosed or misdiagnosed clinically because of diagnostic difficulties caused by lack of laboratory-specific serological markers. In this study, we comprehensively assessed the clinical characteristics, laboratory indices, hepatotoxic drugs, risk factors and outcomes concerning DILI, and explored the similarities in mechanisms between Chinese and Western drug-induced DILI. Patients with a first diagnosis of DILI and a Roussel Uclaf Causality Assessment Method (RUCAM) score >3 points were enrolled for systematic retrospective study. Their clinical characteristics, clinical classification, risk factors, laboratory indices, hepatotoxic drugs and outcomes were analyzed. Cholestatic patients had the highest alkaline phosphatase (ALP) and prothrombin time activity (PTA) levels (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2016.3627