In vitro thrombolytic activity of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.)

Introduction: Thrombotic disorders are among the major fatal conditions affecting the society. Treatment modalities used for such disorders are either surgical interventions or use of drugs such as urokinase, streptokinase (SK), or tissue plasminogen activators to dissolve the blood clots. These mod...

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Bibliographic Details
Published in:Ayu 2015-10, Vol.36 (4), p.421-424
Main Authors: Chaudhary, Shweta, Godatwar, Pawan, Sharma, Reetu
Format: Article
Language:English
Subjects:
Ayurvedic medicine
Blood clots
Catheters
Drugs
Embolisms
Herbal medicine
Hypertension
Medical research
Mortality
Oxidative stress
Pharmacological Study
Studies
Thrombolytic drugs
Thrombosis
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Summary:Introduction: Thrombotic disorders are among the major fatal conditions affecting the society. Treatment modalities used for such disorders are either surgical interventions or use of drugs such as urokinase, streptokinase (SK), or tissue plasminogen activators to dissolve the blood clots. These modalities have their own limitations and side effects apart from being expensive. There is a need for safer and cost effective antithrombolytic agents. Aim: To evaluate in vitro thrombolytic property of Dhamasa (Fagonia arabica Linn.), Kushta (Saussurea lappa Decne.), and Guduchi (Tinospora cordifolia Thunb.) plant extract. Materials and Methods: Venous blood drawn from 20 healthy volunteers was allowed to form clots which was weighed and treated with the extract of test plant materials to disrupt the clots. Weight of clot after and before treatment provided a percentage of clot lysis. SK was used as a positive and water as a negative control. Statistical Analysis Used: The significance between % clot lysis of five groups by means of weight difference was tested by the one-way ANOVA. Results: Clot lysis observed were 68.06%, 14.85%, 25.01%, 92.54%, and 3.00% for Dhamasa, Kushta, Guduchi, SK, and distilled water, respectively. Conclusion: Herbal extracts possess thrombolytic properties and lyse blood clots in vitro.
ISSN:0974-8520
0976-9382
DOI:10.4103/0974-8520.190697