Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model

There is a link between depression, cardiovascular events and inflammation. We have explored this connection through endothelial dysfunction, using in vivo and in vitro approaches. We evaluated circulating biomarkers of endothelial dysfunction in patients with major depression at their diagnosis (MD...

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Bibliographic Details
Published in:Translational psychiatry 2016-09, Vol.6 (9), p.e886-e886
Main Authors: Lopez-Vilchez, I, Diaz-Ricart, M, Navarro, V, Torramade, S, Zamorano-Leon, J, Lopez-Farre, A, Galan, A M, Gasto, C, Escolar, G
Format: Article
Language:English
Subjects:
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Adult
Behavioral Sciences
Biological Psychology
Case-Control Studies
Citalopram - therapeutic use
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - metabolism
Endothelial Progenitor Cells - cytology
Endothelium, Vascular - metabolism
Extracellular Matrix
Female
Human Umbilical Vein Endothelial Cells - metabolism
Humans
In Vitro Techniques
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Nitric Oxide Synthase Type III - metabolism
Original
original-article
Oxidative Stress
Pharmacotherapy
Platelet Activation
Psychiatry
Reactive Oxygen Species - metabolism
Serotonin Uptake Inhibitors - therapeutic use
Thromboplastin - metabolism
Thrombosis - metabolism
Treatment Outcome
Vascular Cell Adhesion Molecule-1 - metabolism
von Willebrand Factor - metabolism
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Summary:There is a link between depression, cardiovascular events and inflammation. We have explored this connection through endothelial dysfunction, using in vivo and in vitro approaches. We evaluated circulating biomarkers of endothelial dysfunction in patients with major depression at their diagnosis (MD-0) and during antidepressant treatment with the selective serotonin reuptake inhibitor escitalopram, for 8 and 24 weeks (MD-8 and MD-24). Results were always compared with matched healthy controls (CON). We measured in vivo circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) in blood samples, and assessed plasma levels of soluble von Willebrand factor (VWF) and vascular cell adhesion molecule-1 (VCAM-1). CEC counts, soluble VWF and VCAM-1 were statistically elevated in MD-0 ( P
ISSN:2158-3188
2158-3188
DOI:10.1038/tp.2016.156