Sex differences in corticotropin releasing factor-evoked behavior and activated networks

Highlights • Corticotropin releasing factor (CRF) evokes more grooming in female than male rats. • Circulating ovarian hormones moderate the sex difference in CRF-evoked grooming. • CRF-activated functional connectivity networks differ based on hormonal status. • Hormonal regulation of stress circui...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-11, Vol.73, p.204-216
Main Authors: Wiersielis, Kimberly R, Wicks, Brittany, Simko, Hannah, Cohen, Sarah R, Khantsis, Sabina, Baksh, Nausheen, Waxler, David E, Bangasser, Debra A
Format: Article
Language:English
Subjects:
Animals
Anxiety
Brain - drug effects
Brain - metabolism
Corticotropin releasing hormone
Corticotropin-Releasing Hormone - administration & dosage
Corticotropin-Releasing Hormone - pharmacology
Endocrinology & Metabolism
Estrogens
Estrogens - metabolism
Estrous Cycle - metabolism
Female
Grooming - drug effects
Male
Progesterone
Progesterone - metabolism
Psychiatry
Rats
Rats, Sprague-Dawley
Sex difference
Sex Factors
Stress
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Summary:Highlights • Corticotropin releasing factor (CRF) evokes more grooming in female than male rats. • Circulating ovarian hormones moderate the sex difference in CRF-evoked grooming. • CRF-activated functional connectivity networks differ based on hormonal status. • Hormonal regulation of stress circuitry may establish sex differences in anxiety
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.07.007