Immune analysis of expression of IL-17 relative ligands and their receptors in bladder cancer: comparison with polyp and cystitis

• Published in: BMC immunology 2016-10, Vol.17 (1), p.36-36, Article 36
• Main Authors: Liu, Yanbo, Yang, Wanguo, Zhao, Lijing, Liang, Zuowen, Shen, Weigao, Hou, Qinlong, Wang, Zhenjiang, Jiang, Jing, Ying, Sun
• Format: Article
• Language: English
• Subjects: Antibodies - blood; Bladder cancer; Carcinogenesis; Cell receptors; Cells, Cultured; Cystitis - complications; Cystitis - immunology; Development and progression; Gene expression; Gene Expression Regulation; Genetic aspects; Humans; Immunohistochemistry; Immunology; Interleukin-17 - genetics; Interleukin-17 - metabolism; Interleukins; Male; Neutrophils - immunology; Physiological aspects; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Polyps - complications; Polyps - immunology; Prostate - immunology; Prostatic Hyperplasia; Thy-1 Antigens - metabolism; Urinary Bladder Neoplasms - complications; Urinary Bladder Neoplasms - immunology; Urinary Tract - immunology
• ISSN: 1471-2172; 1471-2172
• DOI: 10.1186/s12865-016-0174-8

Bladder cancer, cystitis and bladder polyp are the most common urinary system diseases all over the world. Our former research results show that IL-17A and IL-17 F contribute to the pathogenesis of benign prostatic hyperplasia (BPH) and prostate cancer (Pca) while IL-17E interacting with IL-17RB might have an anti-tumor effect. Using imunohistochemistry, we systemically compared immunoreactivity of ligands (IL-17A, E and F) and receptors (IL-17RA, IL-17RB and IL-17RC) of IL-17 family, infiltration of inflammatory cells and changes of structural cells (fibroblast cells, smooth muscle and vascular endothelial cells) in sections of bladder tissues from subjects with bladder cancer, cystitis and bladder polyp. Compared with subjects with cystitis, immunoreactivity for IL-17A, IL-17 F and IL-17RC was significantly elevated in the group of bladder cancer (p