Ebola Virus Epidemiology and Evolution in Nigeria

Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for 12 of the 20. The detailed contact data permits nearly compl...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 2016-10, Vol.214 (suppl 3), p.S102-S109
Main Authors: Folarin, Onikepe A., Ehichioya, Deborah, Schaffner, Stephen F., Winnicki, Sarah M., Wohl, Shirlee, Eromon, Philomena, West, Kendra L., Gladden-Young, Adrianne, Oyejide, Nicholas E., Matranga, Christian B., Deme, Awa Bineta, James, Ayorinde, Tomkins-Tinch, Christopher, Onyewurunwa, Kenneth, Ladner, Jason T., Palacios, Gustavo, Nosamiefan, Iguosadolo, Andersen, Kristian G., Omilabu, Sunday, Park, Daniel J., Yozwiak, Nathan L., Nasidi, Abdusallam, Garry, Robert F., Tomori, Oyewale, Sabeti, Pardis C., Happi, Christian T.
Format: Article
Language:English
Subjects:
Adult
Biological Evolution
Disease Outbreaks
Ebola Outbreak in West Africa
Ebolavirus - genetics
Ebolavirus - isolation & purification
EPIDEMIOLOGY
Female
Genome, Viral - genetics
Hemorrhagic Fever, Ebola - epidemiology
Hemorrhagic Fever, Ebola - transmission
Hemorrhagic Fever, Ebola - virology
Humans
Liberia
Male
Middle Aged
Nigeria - epidemiology
Phylogeny
Sequence Analysis, DNA
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Summary:Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for 12 of the 20. The detailed contact data permits nearly complete reconstruction of the transmission tree for the outbreak. The EBOV genomic data are consistent with that tree. It confirms that there was a single source for the Nigerian infections, shows that the Nigerian EBOV lineage nests within a lineage previously seen in Liberia but is genetically distinct from it, and supports the conclusion that transmission from Nigeria to elsewhere did not occur.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiw190