Ophthalmic molluscum contagiosum: clinical and immunopathological features

AIMS--A study of ophthalmic molluscum contagiosum infection was undertaken to define its clinical presentation and immunopathological features. METHODS--Retrospective analysis of 35 cases of histologically proved molluscum contagiosum infection was carried out. Diagnosis was delayed in 40% of cases...

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Bibliographic Details
Published in:British journal of ophthalmology 1995-05, Vol.79 (5), p.476-481
Main Authors: Charteris, D G, Bonshek, R E, Tullo, A B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Female
Human viral diseases
Humans
Immunohistochemistry
Infectious diseases
Keratitis - immunology
Keratitis - pathology
Keratitis - virology
Macrophages - pathology
Male
Medical sciences
Middle Aged
Molluscum Contagiosum - diagnosis
Molluscum Contagiosum - immunology
Molluscum Contagiosum - pathology
Retrospective Studies
T-Lymphocytes - immunology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Summary:AIMS--A study of ophthalmic molluscum contagiosum infection was undertaken to define its clinical presentation and immunopathological features. METHODS--Retrospective analysis of 35 cases of histologically proved molluscum contagiosum infection was carried out. Diagnosis was delayed in 40% of cases resulting in repeated clinic visits. RESULTS--Twenty one patients were noted to have ocular surface changes; two patients were immunocompromised. All cases were eventually treated by excision of the lesion (19 had cautery to the lesion base) and there was recurrence in two cases. Immunohistochemical analysis of biopsy specimens showed that T lymphocytes were a consistent finding in adjacent dermis and epidermis although they did not infiltrate the molluscum lesions. Smaller numbers of macrophages were also demonstrated. There was a notable cross reactivity by a T cell antibody to the molluscum bodies. CONCLUSION--The study shows the varied presentation of molluscum contagiosum infection to the ophthalmologist and the nature of the local immune response to the virus.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.79.5.476