Histopathology and treatment of a huge overhanging filtering bleb

The giant filtering bleb encroaching onto the corneal surface is a rare occurrence in our and other's clinical experience (Kapoor and Syed, Int. Ophthalmol 31(5):403-404, 2011), even in patients having had a trabeculectomy with mitomycin C, and how it developed is debated. In this paper, we rep...

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Bibliographic Details
Published in:BMC ophthalmology 2016-10, Vol.16 (1), p.175, Article 175
Main Authors: Ou-Yang, Ping-Bo, Qi, Xin, Duan, Xuan-Chu
Format: Article
Language:English
Subjects:
Analysis
Blister - pathology
Blister - surgery
Care and treatment
Case Report
Conjunctival Diseases - pathology
Conjunctival Diseases - surgery
Corneal Diseases - pathology
Corneal Diseases - surgery
Female
Glaucoma
Histology, Pathological
Humans
Immunohistochemistry
Influence
Middle Aged
Mitomycin
Ophthalmology
Postoperative Complications - pathology
Postoperative Complications - surgery
Trabeculectomy - adverse effects
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Summary:The giant filtering bleb encroaching onto the corneal surface is a rare occurrence in our and other's clinical experience (Kapoor and Syed, Int. Ophthalmol 31(5):403-404, 2011), even in patients having had a trabeculectomy with mitomycin C, and how it developed is debated. In this paper, we report a patient who developed a huge overhanging filtering bleb after trabeculectomy, and present our intraoperative photographs, histopathology and immunohistochemistry results. A 62-year-old female visited our hospital due to the giant filtering bleb encroaching onto the corneal surface which was about 6 mm × 8 mm × 3 mm. We dissected the filtering bleb from the cornea and present the histopathology and immunohistochemistry results of it. The results from histopathology and immunohistochemistry in this study are consistent with the filtering cicatrix hypothesis. However, our finding that the overhanging blebs had tight connections with the corneal tissue or corneoscleral limbus, rather than simply leaning on it, might be highly related to their development and still needs to be further studied.
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-016-0353-7