Rationale and Design of the CREDENCE Trial: computed TomogRaphic evaluation of atherosclerotic DEtermiNants of myocardial IsChEmia

Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of obstructive coronary artery disease (CAD) beyond measures of stenosis severity alone. This assessment includes atherosclerotic plaque characteristics (APCs) and calculation of fractional flow reserve (FFR) from CCT...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2016-10, Vol.16 (1), p.190-190, Article 190
Main Authors: Rizvi, Asim, Hartaigh, Bríain Ó, Knaapen, Paul, Leipsic, Jonathon, Shaw, Leslee J, Andreini, Daniele, Pontone, Gianluca, Raman, Subha, Khan, Muhammad Akram, Ridner, Michael, Nabi, Faisal, Gimelli, Alessia, Jang, James, Cole, Jason, Nakazato, Ryo, Zarins, Christopher, Han, Donghee, Lee, Ji Hyun, Szymonifika, Jackie, Gomez, Millie J, Truong, Quynh A, Chang, Hyuk-Jae, Lin, Fay Y, Min, James K
Format: Article
Language:English
Subjects:
Adult
Analysis
Blood flow
Care and treatment
Clinical trials
Coronary Angiography - methods
Coronary Artery Disease - diagnosis
Coronary Artery Disease - physiopathology
Coronary heart disease
CT imaging
Female
Follow-Up Studies
Fractional Flow Reserve, Myocardial
Humans
Male
Myocardial Ischemia - diagnosis
Myocardial Ischemia - physiopathology
Plaque, Atherosclerotic - diagnosis
Plaque, Atherosclerotic - physiopathology
Predictive Value of Tests
Prospective Studies
Radioisotope scanning
Reproducibility of Results
Severity of Illness Index
Study Protocol
Tomography, X-Ray Computed - methods
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Summary:Coronary computed tomography angiography (CCTA) allows for non-invasive assessment of obstructive coronary artery disease (CAD) beyond measures of stenosis severity alone. This assessment includes atherosclerotic plaque characteristics (APCs) and calculation of fractional flow reserve (FFR) from CCTA (FFR ). Similarly, stress imaging by myocardial perfusion scintigraphy (MPS) provides vital information. To date, the diagnostic performance of integrated CCTA assessment versus integrated MPS assessment for diagnosis of vessel-specific ischemia remains underexplored. CREDENCE will enroll adult individuals with symptoms suspicious of CAD referred for non-emergent invasive coronary angiography (ICA), but without known CAD. All participants will undergo CCTA, MPS, ICA and FFR. FFR will be performed for lesions identified at the time of ICA to be ≥40 and
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-016-0360-x