Stem cell transplantation in adults with acute myelogenous leukemia, normal cytogenetics, and the FLT3-ITD mutation

Highlights • Patients with FLT3 + AML have poor prognosis with chemotherapy alone. • We reviewed a single center experience with SCT in FLT3 + patients. • Stem cell transplant can abrogate the poor prognosis in FLT3 + AML patients.

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Bibliographic Details
Published in:Leukemia research 2016-01, Vol.40, p.33-37
Main Authors: Berman, Ellin, Maloy, Molly, Devlin, Sean, Jhanwar, Suresh, Papadopoulos, Esperanza, Jakubowski, Ann
Format: Article
Language:English
Subjects:
AML
FLT3-ITD
fms-Like Tyrosine Kinase 3 - genetics
Hematology, Oncology and Palliative Medicine
Humans
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - therapy
Mutation
Retrospective Studies
Stem cell transplant
Stem Cell Transplantation
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Description
Summary:Highlights • Patients with FLT3 + AML have poor prognosis with chemotherapy alone. • We reviewed a single center experience with SCT in FLT3 + patients. • Stem cell transplant can abrogate the poor prognosis in FLT3 + AML patients.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.11.010