Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin

Obesity results in increased secretion of cytokines from adipose tissue and is a risk factor for various cancers. Leptin is largely produced by adipose tissue and cancer cells. It induces cell proliferation and may serve to induce various cancers. OB3-leptin peptide (OB3) is a new class of functiona...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget 2016-05, Vol.7 (19), p.27641-27654
Main Authors: Yang, Yu-Chen Sh, Chin, Yu-Tang, Hsieh, Meng-Ti, Lai, Hsuan-Yu, Ke, Chien-Chih, Crawford, Dana R, Lee, Oscar K, Fu, Earl, Mousa, Shaker A, Grasso, Patricia, Liu, Leroy F, Chang, Heng-Yu, Tang, Heng-Yuan, Lin, Hung-Yun, Davis, Paul J
Format: Article
Language:English
Subjects:
Animals
Carbohydrate Metabolism - drug effects
Cell Line, Tumor
Cell Proliferation - drug effects
Disease Progression
Humans
Leptin - metabolism
Leptin - pharmacokinetics
Leptin - pharmacology
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Peptide Fragments - metabolism
Peptide Fragments - pharmacology
Random Allocation
Research Paper
Signal Transduction
Thyroid Neoplasms - blood
Thyroid Neoplasms - genetics
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
Thyrotropin - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obesity results in increased secretion of cytokines from adipose tissue and is a risk factor for various cancers. Leptin is largely produced by adipose tissue and cancer cells. It induces cell proliferation and may serve to induce various cancers. OB3-leptin peptide (OB3) is a new class of functional leptin peptide. However, its mitogenic effect has not been determined. In the present study, because of a close link between leptin and the hypothalamic-pituitary-thyroid axis, OB3 was compared with leptin in different thyroid cancer cells for gene expression, proliferation and invasion. Neither agent stimulated cell proliferation. Leptin stimulated cell invasion, but reduced adhesion in anaplastic thyroid cancer cells. Activated ERK1/2 and STAT3 contributed to leptin-induced invasion. In contrast, OB3 did not affect expression of genes involved in proliferation and invasion. In vivo studies in the mouse showed that leptin, but not OB3, significantly increased circulating levels of thyrotropin (TSH), a growth factor for thyroid cancer. In summary, OB3 is a derivative of leptin that importantly lacks the mitogenic effects of leptin on thyroid cancer cells.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.8505