Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Active data screening is an integral part of many scientific activities, and mobile technologies have greatly facilitated this process by minimizing the reliance on large hardware instrumentation. In order to meet with the increasingly growing field of metabolomics and heavy workload of data process...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2016-10, Vol.88 (19), p.9753-9758
Main Authors: Montenegro-Burke, J. Rafael, Phommavongsay, Thiery, Aisporna, Aries E., Huan, Tao, Rinehart, Duane, Forsberg, Erica, Poole, Farris L., Thorgersen, Michael P., Adams, Michael W. W., Krantz, Gregory, Fields, Matthew W., Northen, Trent R., Robbins, Paul D., Niedernhofer, Laura J., Lairson, Luke, Benton, H. Paul, Siuzdak, Gary
Format: Article
Language:English
Subjects:
Applications programs
Bacteria
Chromatography, Liquid
Data Interpretation, Statistical
Data processing
Humans
Internet
Mass Spectrometry
MATHEMATICS AND COMPUTING
Metabolism
Metabolomics
Mobile Applications
Mobile communication systems
Mobile operating systems
Platforms
Principal Component Analysis
Principal components analysis
Screening
Smartphone
Smartphones
Visualization
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Summary:Active data screening is an integral part of many scientific activities, and mobile technologies have greatly facilitated this process by minimizing the reliance on large hardware instrumentation. In order to meet with the increasingly growing field of metabolomics and heavy workload of data processing, we designed the first remote metabolomic data screening platform for mobile devices. Two mobile applications (apps), XCMS Mobile and METLIN Mobile, facilitate access to XCMS and METLIN, which are the most important components in the computer-based XCMS Online platforms. These mobile apps allow for the visualization and analysis of metabolic data throughout the entire analytical process. Specifically, XCMS Mobile and METLIN Mobile provide the capabilities for remote monitoring of data processing, real time notifications for the data processing, visualization and interactive analysis of processed data (e.g., cloud plots, principle component analysis, box-plots, extracted ion chromatograms, and hierarchical cluster analysis), and database searching for metabolite identification. These apps, available on Apple iOS and Google Android operating systems, allow for the migration of metabolomic research onto mobile devices for better accessibility beyond direct instrument operation. The utility of XCMS Mobile and METLIN Mobile functionalities was developed and is demonstrated here through the metabolomic LC-MS analyses of stem cells, colon cancer, aging, and bacterial metabolism.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.6b02676