Crosstalk in skin: melanocytes, keratinocytes, stem cells, and melanoma

In the vertebrate embryo, melanocytes arise from the neural crest, migrate to and colonize the basal layer within the skin and skin appendages. Post-migratory melanocytes are securely attached to the basement membrane, and their morphology, growth, adhesion, and migration are under control of neighb...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cell communication and signaling 2016-09, Vol.10 (3), p.191-196
Main Authors: Wang, Joshua X., Fukunaga-Kalabis, Mizuho, Herlyn, Meenhard
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell interactions
Cell proliferation
Cell self-renewal
Cell‐cell interaction
Genetic transformation
Homeostasis
Keratinocytes
Keratiocyte
Life Sciences
Melanocyte
Melanocytes
Melanoma
Neural crest
Neural stem cells
Review
Skin
Stem cell
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the vertebrate embryo, melanocytes arise from the neural crest, migrate to and colonize the basal layer within the skin and skin appendages. Post-migratory melanocytes are securely attached to the basement membrane, and their morphology, growth, adhesion, and migration are under control of neighboring keratinocytes. Melanoma is a malignant tumor originated from melanocytes or their progenitor cells. During melanocyte transformation and melanoma progression, melanocytes lose their interactions with keratinocytes, resulting in uncontrolled proliferation and invasion of the malignant cells. Melanoma cells at the advanced stages often lack melanocytic features and resemble multipotent progenitors, which are a potential melanocyte reservoir in human skin. In this mini-review, we will summarize findings on cell-cell interactions that are responsible for normal melanocyte homeostasis, stem cell self-renewal, and differentiation. Our ultimate goal is to define molecules and pathways, which are essential for normal cell-cell interactions but deregulated in melanoma formation and progression.
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-016-0349-3