A nomogram for predicting survival of nasopharyngeal carcinoma patients with metachronous metastasis

Patients with metachronous metastatic nasopharyngeal carcinoma (NPC) differ significantly in survival outcomes. The aim of this study is to build a clinically practical nomogram incorporating known tumor prognostic factors to predict survival for metastatic NPC patients in epidemic areas.A total of...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-07, Vol.95 (27), p.e4026-e4026
Main Authors: Zeng, Zixun, Shen, Lujun, Wang, Yue, Shi, Feng, Chen, Chen, Wu, Ming, Bai, Yutong, Pan, Changchuan, Xia, Yunfei, Wu, Peihong, Li, Wang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Bone Neoplasms - drug therapy
Bone Neoplasms - mortality
Bone Neoplasms - secondary
Carcinoma
Child
China - epidemiology
Humans
Liver Neoplasms - drug therapy
Liver Neoplasms - mortality
Liver Neoplasms - secondary
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - drug therapy
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - pathology
Neoplasm Staging
Nomograms
Observational Study
Palliative Care
Prognosis
Retrospective Studies
Risk Factors
Survival Analysis
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Summary:Patients with metachronous metastatic nasopharyngeal carcinoma (NPC) differ significantly in survival outcomes. The aim of this study is to build a clinically practical nomogram incorporating known tumor prognostic factors to predict survival for metastatic NPC patients in epidemic areas.A total of 860 patients with metachronous metastatic nasopharyngeal carcinoma were analyzed retrospectively. Variables assessed were age, gender, body mass index, Karnofsky Performance Status (KPS), Union for International Cancer Control (UICC) T and N stages, World Health Organization (WHO) histology type, serum lactate dehydrogenase (sLDH) level, serum Epstein-Barr virus (EBV) level, treatment modality, specific metastatic location (lung/liver/bone), number of metastatic location(s) (isolated vs multiple), and number of metastatic lesion(s) in metastatic location(s) (single vs multiple). The independent prognostic factors for overall survival (OS) by Cox-regression model were utilized to build the nomogram.Independent prognostic factors for OS of metastatic NPC patients included age, UICC N stage, KPS, sLDH, number of metastatic locations, number of metastatic lesions, involvement of liver metastasis, and involvement of bone metastasis. Calibration of the final model suggested a c-index of 0.68 (95% confidence interval [CI], 0.65-0.69). Based on the total point (TP) by nomogram, we further subdivided the study cohort into 4 groups. Group 1 (TP 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000004026