Proposal for a new T-stage classification system for distal cholangiocarcinoma: a 10-institution study from the U.S. Extrahepatic Biliary Malignancy Consortium

Abstract Background Seventh AJCC distal cholangiocarcinoma T-stage classification inadequately separates patients by survival. This retrospective study aimed to define a novel T-stage system to better stratify patients after resection. Methods Curative-intent pancreaticoduodenectomies for distal cho...

Full description

Saved in:
Bibliographic Details
Published in:HPB (Oxford, England) England), 2016-10, Vol.18 (10), p.793-799
Main Authors: Postlewait, Lauren M, Ethun, Cecilia G, Le, Nina, Pawlik, Timothy M, Buettner, Stefan, Poultsides, George, Tran, Thuy, Idrees, Kamran, Isom, Chelsea A, Fields, Ryan C, Krasnick, Bradley, Weber, Sharon M, Salem, Ahmed, Martin, Robert C.G, Scoggins, Charles, Shen, Perry, Mogal, Harveshp D, Schmidt, Carl, Beal, Eliza, Hatzaras, Ioannis, Vitiello, Gerardo, Cardona, Kenneth, Maithel, Shishir K
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bile Duct Neoplasms - classification
Bile Duct Neoplasms - mortality
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Cholangiocarcinoma - classification
Cholangiocarcinoma - mortality
Cholangiocarcinoma - pathology
Cholangiocarcinoma - surgery
Female
Gastroenterology and Hepatology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Neoplasm Invasiveness
Neoplasm Staging - methods
Original
Pancreaticoduodenectomy - adverse effects
Pancreaticoduodenectomy - mortality
Proportional Hazards Models
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Tumor Burden
United States
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Seventh AJCC distal cholangiocarcinoma T-stage classification inadequately separates patients by survival. This retrospective study aimed to define a novel T-stage system to better stratify patients after resection. Methods Curative-intent pancreaticoduodenectomies for distal cholangiocarcinoma (1/2000-5/2015) at 10 US institutions were included. Relationships between tumor characteristics and overall survival (OS) were assessed and incorporated into a novel T-stage classification. Results 176 patients (median follow-up: 24mo) were included. Current AJCC T-stage was not associated with OS (T1: 23mo, T2: 20mo, T3: 25mo, T4: 12mo; p = 0.355). Tumor size ≥3 cm and presence of lymphovascular invasion (LVI) were associated with decreased OS on univariate and multivariable analyses. Patients were stratified into 3 groups [T1: size
ISSN:1365-182X
1477-2574
DOI:10.1016/j.hpb.2016.07.009