Ascaris Hemoglobin Gene: Plant-Like Structure Reflects the Ancestral Globin Gene

Animal globin genes have two introns at strictly conserved positions, while plant globin genes have both of these as well as an additional, central intron. It has been proposed that a common ancestor gene had three introns, one of which was subsequently lost from animal but not plant globin genes. W...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1992-12, Vol.89 (24), p.11696-11700
Main Authors: Sherman, David R., Kloek, Andrew P., Krishnan, B. Rajendra, Guinn, Brett, Goldberg, Daniel E.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Ascaris
Ascaris - genetics
Base Sequence
Biological and medical sciences
Biological Evolution
cDNA
Complementary DNA
DNA
DNA - genetics
Fundamental and applied biological sciences. Psychology
Generally accepted auditing standards
Genes
Genes, Plant
Genes. Genome
Genetics
Genomics
Globins - genetics
haemoglobin
Hemoglobins
Introns
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Nematodes
nucleotide sequence
Oligodeoxyribonucleotides - chemistry
Oxygen
Parasites
phylogeny
Polymerase Chain Reaction
predictions
Proteins
Sequence Alignment
Worms
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Summary:Animal globin genes have two introns at strictly conserved positions, while plant globin genes have both of these as well as an additional, central intron. It has been proposed that a common ancestor gene had three introns, one of which was subsequently lost from animal but not plant globin genes. We have elucidated the cDNA sequence and gene structure of a hemoglobin from the parasitic nematode Ascaris suum and found a plant-like central intron, providing strong evidence for a three-intron ancestor of modern globin genes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.89.24.11696