Complete donor chimerism is a prerequisite for the effect of Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) on acute graft-versus-host disease

Predicted indirectly recognizable HLA epitopes (PIRCHE) computationally predict donor T-cell recognition of mismatched-HLA derived peptides following allogeneic haematopoietic stem-cell transplantation (allo-HSCT), as is evidenced by the correlation between presence of HLA-DPB1-derived PIRCHE and th...

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Bibliographic Details
Published in:Chimerism 2014, Vol.5 (3-4), p.94-98
Main Authors: Thus, Kirsten A, de Weger, Roel A, de Hoop, Talitha A, Boers Trilles, Valeria E, Kuball, Jürgen, Spierings, Eric
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Brief Report
Chimerism
Epitopes - genetics
Epitopes - immunology
Female
Graft vs Host Disease - genetics
Graft vs Host Disease - immunology
Hematopoietic Stem Cell Transplantation
HLA Antigens - genetics
HLA Antigens - immunology
Humans
Male
Middle Aged
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Predicted indirectly recognizable HLA epitopes (PIRCHE) computationally predict donor T-cell recognition of mismatched-HLA derived peptides following allogeneic haematopoietic stem-cell transplantation (allo-HSCT), as is evidenced by the correlation between presence of HLA-DPB1-derived PIRCHE and the occurrence of graft-vs.-host disease (GVHD). Complete donor T-cell chimerism associates with an increased GVHD risk compared to mixed patient and donor chimerism. If the correlation between the presence of PIRCHE and GVHD occurrence is indeed mediated by donor T cells, the presence of donor T cells should be required to observe such a correlation. This study was initiated to investigate whether the effect of PIRCHE is different in patients with complete chimerism compared to those with mixed chimerism. Indeed, the correlation between PIRCHE and GVHD is present in patients with complete chimerism, whereas it is absent in those with mixed chimerism. The data presented here suggest that chimerism status is important for the detection of potential GVHD epitopes.
ISSN:1938-1956
1938-1964
DOI:10.1080/19381956.2015.1097025