Pheochromocytoma in Old World Primates (Macaca mulatta and Chlorocebus aethiops)

Pheochromocytoma, a rarely reported adrenal gland neoplasm in Old World primates, was diagnosed in 5 rhesus macaques (Macaca mulatta) and 2 African green monkeys (Chlorocebus aethiops) from 3 research institutions. Age and sex were available for 6 primates. Two males and 4 females were affected, ran...

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Bibliographic Details
Published in:Veterinary pathology 2016-11, Vol.53 (6), p.1259-1263
Main Authors: Colgin, L. M. A., Schwahn, D. J., Castillo-Alcala, F., Kiupel, M., Lewis, A. D.
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - diagnosis
Adrenal Gland Neoplasms - pathology
Adrenal Gland Neoplasms - veterinary
Adrenal Glands - pathology
Animals
Cercopithecus aethiops
Female
Macaca mulatta
Male
Monkey Diseases - diagnosis
Monkey Diseases - pathology
Pheochromocytoma - diagnosis
Pheochromocytoma - pathology
Pheochromocytoma - veterinary
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Summary:Pheochromocytoma, a rarely reported adrenal gland neoplasm in Old World primates, was diagnosed in 5 rhesus macaques (Macaca mulatta) and 2 African green monkeys (Chlorocebus aethiops) from 3 research institutions. Age and sex were available for 6 primates. Two males and 4 females were affected, ranging in age from 9 to 31 years. All neoplasms were unilateral and, in the cases reporting the affected gland, 4 involved the right adrenal gland and 2 involved the left. Diagnosis was established by characteristic histologic features. Immunohistochemically, neoplastic cells in all cases expressed chromogranin A and met-enkephalin and were negative for melan-A and inhibin. Six of 7 tumors were positive for β-endorphin. Pulmonary metastases were present in 2 rhesus macaques and portal vein invasion in 1 African green monkey. To the authors’ knowledge, this is the first report of malignant pheochromocytoma in Old World primates.
ISSN:0300-9858
1544-2217
DOI:10.1177/0300985816647449