Rabbit models of cardiac mechano-electric and mechano-mechanical coupling

Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as ‘the endpoint’ of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical e...

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Bibliographic Details
Published in:Progress in biophysics and molecular biology 2016-07, Vol.121 (2), p.110-122
Main Authors: Quinn, T. Alexander, Kohl, Peter
Format: Article
Language:English
Subjects:
Animals
Atrium
Biomechanical Phenomena
Electrophysiological Phenomena
Electrophysiology
Heart
Heart - physiology
Humans
Mechanical Phenomena
Mechanics
Models, Cardiovascular
Rabbits
Sinoatrial node
Slow force response
Ventricle
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Summary:Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as ‘the endpoint’ of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical environment to cardiac electrical (mechano-electric coupling, MEC) and mechanical (mechano-mechanical coupling, MMC) activity. MEC and MMC contribute to beat-by-beat adaption of cardiac output to physiological demand, and they are involved in various pathological settings, potentially aggravating cardiac dysfunction. Experimental and computational studies using rabbit as a model species have been integral to the development of our current understanding of MEC and MMC. In this paper we review this work, focusing on physiological and pathological implications for cardiac function.
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2016.05.003