Pulsatile Load Components, Resistive Load and Incident Heart Failure: the Multi-Ethnic Study of Atherosclerosis (MESA)

Highlights • Reflection magnitude and the magnitude of the reflected wave are associated with increased heart failure risk in a large population of healthy community-dwelling individuals, after comprehensive adjustment for risk factors known to associate with heart failure risk and the presence of s...

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Bibliographic Details
Published in:Journal of cardiac failure 2016-12, Vol.22 (12), p.988-995
Main Authors: Zamani, Payman, MD, MTR, Lilly, Scott M., MD, PhD, Segers, Patrick, PhD, Jacobs, David R., PhD, Bluemke, David A., MD, PhD, MsB, Duprez, Daniel A., MD, PhD, Chirinos, Julio A., MD, PhD
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atherosclerosis - complications
Atherosclerosis - ethnology
Atherosclerosis - physiopathology
Blood Pressure - physiology
Cardiovascular
compliance
Ethnic Groups
European Continental Ancestry Group
Female
heart failure
Heart Failure - epidemiology
Heart Failure - physiopathology
Humans
Incidence
Male
Middle Aged
Proportional Hazards Models
Stroke Volume - physiology
vascular resistance
Vascular Resistance - physiology
Wave reflections
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Summary:Highlights • Reflection magnitude and the magnitude of the reflected wave are associated with increased heart failure risk in a large population of healthy community-dwelling individuals, after comprehensive adjustment for risk factors known to associate with heart failure risk and the presence of subclinical atherosclerosis. • Systemic vascular resistance and effective arterial elastance did not independently associate with heart failure. This indicates that resistive arterial load is not related to HF risk, whereas effective arterial elastance, a commonly used parameter of arterial load, fails to capture important prognostic information in pulsatile load patterns. • Our findings emphasize the importance of the loading sequence and of assessing pulsatile load using time-resolved arterial waveforms.
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2016.04.011