Molecular characterization of the first G24P[14] rotavirus strain detected in humans

Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation...

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Published in:Infection, genetics and evolution genetics and evolution, 2016-09, Vol.43, p.338-342
Main Authors: Ward, M. Leanne, Mijatovic-Rustempasic, Slavica, Roy, Sunando, Rungsrisuriyachai, Kunchala, Boom, Julie A., Sahni, Leila C., Baker, Carol J., Rench, Marcia A., Wikswo, Mary E., Payne, Daniel C., Parashar, Umesh D., Bowen, Michael D.
Format: Article
Language:English
Subjects:
Animals
Bovine
Cattle
Child, Preschool
G24P
Genome, Viral
Genotype
High-Throughput Nucleotide Sequencing
Humans
Male
Phylogeny
Reassortant Viruses - classification
Reassortant Viruses - genetics
Reassortment
Rotavirus
Rotavirus - classification
Rotavirus - genetics
Rotavirus Infections - virology
Texas
Viral Nonstructural Proteins - genetics
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Summary:Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans. •First report of G24P[14] genotype in humans•Second report of G24 genotype overall•Four genes are similar to bovine rotavirus strains.•Other genes resemble animal and human strains.•This strain is likely the product of multiple reassortant events.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2016.05.033