Putting the brakes on the brakes: negative emotion disrupts cognitive control network functioning and alters subsequent stopping ability

• Published in: Experimental brain research 2016-11, Vol.234 (11), p.3107-3118
• Main Authors: Patterson, Tara K., Lenartowicz, Agatha, Berkman, Elliot T., Ji, Danni, Poldrack, Russell A., Knowlton, Barbara J.
• Format: Article
• Language: English
• Subjects: Adolescent; Affective Symptoms - complications; Biomedical and Life Sciences; Biomedicine; Brain - diagnostic imaging; Brain - physiopathology; Brain Mapping; Brain research; Cognitive Dysfunction - etiology; Emotions; Experiments; Female; Humans; Image Processing, Computer-Assisted; Imagination; Inhibition (Psychology); Magnetic Resonance Imaging; Male; Negative reinforcement; Neural networks; Neurology; Neurosciences; Oxygen - blood; Photic Stimulation; Psychological research; Psychomotor performance; Psychophysics; Reaction Time - physiology; Research Article; Task Performance and Analysis; Young Adult
• ISSN: 0014-4819; 1432-1106
• DOI: 10.1007/s00221-016-4709-2

The ability to inhibit unwanted responses is critical for effective control of behavior, and inhibition failures can have disastrous consequences in real-world situations. Here, we examined how prior exposure to negative emotional stimuli affects the response-stopping network. Participants performed the stop-signal task, which relies on inhibitory control processes, after they viewed blocks of either negatively emotional or neutral images. In Experiment 1, we found that neural activity was reduced following negative image viewing. When participants were required to inhibit responding after neutral image viewing, we observed activation consistent with previous studies using the stop-signal task. However, when participants were required to inhibit responding after negative image viewing, we observed reductions in the activation of ventrolateral prefrontal cortex, dorsolateral prefrontal cortex, medial frontal cortex, and parietal cortex. Furthermore, analysis of neural connectivity during stop-signal task blocks indicated that across participants, emotion-induced changes in behavioral performance were associated with changes in functional connectivity, such that greater behavioral impairment after negative image viewing was associated with greater weakening of connectivity. In Experiment 2, we collected behavioral data from a larger sample of participants and found that stopping performance was impaired after negative image viewing, as seen in longer stop-signal reaction times. The present results demonstrate that negative emotional events can prospectively disrupt the neural network supporting response inhibition.