Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins

ABSTRACT How host–virus co‐evolutionary relationships manifest is one of the most intriguing issues in virology. To address this topic, the mammal–lentivirus relationship can be considered as an interplay of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic pol...

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Bibliographic Details
Published in:Microbiology and immunology 2016-04, Vol.60 (4), p.272-279
Main Authors: Yoshikawa, Rokusuke, Nakano, Yusuke, Yamada, Eri, Izumi, Taisuke, Misawa, Naoko, Koyanagi, Yoshio, Sato, Kei
Format: Article
Language:English
Subjects:
Animals
APOBEC Deaminases
apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3
Cats
Cytidine Deaminase
Cytosine Deaminase - genetics
Cytosine Deaminase - metabolism
Evolution, Molecular
feline immunodeficiency virus
Gene Products, vif - genetics
Gene Products, vif - immunology
Gene Products, vif - metabolism
Host-Pathogen Interactions
Immunity, Innate
Immunodeficiency Virus, Feline - genetics
Immunodeficiency Virus, Feline - immunology
Immunodeficiency Virus, Feline - metabolism
Lentivirus
Proteins
Puma
Species Specificity
viral infectivity factor
Virus Diseases - veterinary
Virus Replication
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Summary:ABSTRACT How host–virus co‐evolutionary relationships manifest is one of the most intriguing issues in virology. To address this topic, the mammal–lentivirus relationship can be considered as an interplay of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic polypeptide‐like 3 (APOBEC3) and viral infectivity factor (Vif). APOBEC3s enzymatically restrict lentivirus replication, whereas Vif antagonizes the host anti‐viral action mediated by APOBEC3. In this study, the focus was on the interplay between feline APOBEC3 proteins and two feline immunodeficiency viruses in cats and pumas. To our knowledge, this study provides the first evidence of non‐primate lentiviral Vif being incapable of counteracting a natural host's anti‐viral activity mediated via APOBEC3 protein.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12371