Association of urinary melatonin levels and aging-related outcomes in older men

Highlights • Urinary melatonin levels, measured at a single point in later life, were not associated with cognitive or physical function in this cohort of older men. • These melatonin levels also were not related to mortality, including cardiovascular-related mortality, in this cohort. • Further res...

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Bibliographic Details
Published in:Sleep medicine 2016-07, Vol.23, p.73-80
Main Authors: Devore, Elizabeth E., ScD, Harrison, Stephanie L., MPH, Stone, Katie L., PhD, Holton, Kathleen F., PhD, Barrett-Connor, Elizabeth, MD, Ancoli-Israel, Sonia, PhD, Yaffe, Kristine, MD, Ensrud, Kristine, MD, Cawthon, Peggy M., PhD, Redline, Susan, MD, Orwoll, Eric, MD, Schernhammer, Eva S., MD
Format: Article
Language:English
Subjects:
Aged
Aging
Aging - physiology
Aging - urine
Cardiovascular Diseases - mortality
Cognition - physiology
Cognitive function
Cohort Studies
Humans
Male
Melatonin
Melatonin - analogs & derivatives
Melatonin - physiology
Melatonin - urine
Mortality
Neurology
Physical Fitness - physiology
Physical function
Sleep Medicine
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Summary:Highlights • Urinary melatonin levels, measured at a single point in later life, were not associated with cognitive or physical function in this cohort of older men. • These melatonin levels also were not related to mortality, including cardiovascular-related mortality, in this cohort. • Further research should explore melatonin levels, particularly if assessed earlier in life, and other circadian markers with health aging outcomes in older men and women.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2016.07.006