Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains

A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC values for the azole-susceptible strains were 0.001 μg/...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2016-11, Vol.60 (11), p.6916-6919
Main Authors: Abastabar, Mahdi, Rahimi, Nooshin, Meis, Jacques F, Aslani, Narges, Khodavaisy, Sadegh, Nabili, Mojtaba, Rezaei-Matehkolaei, Ali, Makimura, Koichi, Badali, Hamid
Format: Article
Language:English
Subjects:
Antifungal Agents
Antifungal Agents - pharmacology
Aspergillus fumigatus
Aspergillus fumigatus - drug effects
Aspergillus fumigatus - genetics
Aspergillus fumigatus - isolation & purification
Azoles - pharmacology
Drug Resistance, Fungal
Drug Resistance, Fungal - drug effects
Humans
Imidazoles
Imidazoles - pharmacology
Microbial Sensitivity Tests
Susceptibility
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Summary:A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01193-16