Clinical Charateristics and Outcome of Pyogenic Liver Abscess with Different Size: 15-Year Experience from a Single Center

The standard therapeutic protocols of pyogenic liver abscess (PLA) have not been well established yet. We investigated the clinical characteristics, disease progression, choices of treatments and outcomes of PLA with different size. 410 cases of patients with PLA were enrolled retrospectively from 2...

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Bibliographic Details
Published in:Scientific reports 2016-10, Vol.6 (1), p.35890-35890, Article 35890
Main Authors: Du, Zhao-Qing, Zhang, Li-Na, Lu, Qiang, Ren, Yi-Fan, Lv, Yi, Liu, Xue-Min, Zhang, Xu-Feng
Format: Article
Language:English
Subjects:
692/308/409
692/4020/4021/288
Adolescent
Adult
Aged
Aged, 80 and over
Albumin
Anti-Infective Agents - therapeutic use
Antibiotics
Bacteria - classification
Bacteria - isolation & purification
Bacterial Infections - pathology
Bacterial Infections - therapy
Blood culture
Body temperature
Child
Child, Preschool
Drainage
E coli
Female
Fungi - classification
Fungi - isolation & purification
Humanities and Social Sciences
Humans
Infant
Leukocytes
Liver
Liver Abscess, Pyogenic - pathology
Liver Abscess, Pyogenic - therapy
Male
Middle Aged
Morbidity
multidisciplinary
Mycoses - pathology
Mycoses - therapy
Phospholipase A
Pneumonia
Retrospective Studies
Science
Science (multidisciplinary)
Temperature effects
Trauma
Treatment Outcome
Wound drainage
Young Adult
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Summary:The standard therapeutic protocols of pyogenic liver abscess (PLA) have not been well established yet. We investigated the clinical characteristics, disease progression, choices of treatments and outcomes of PLA with different size. 410 cases of patients with PLA were enrolled retrospectively from 2000 to 2014, and were grouped as small abscess (≤5 cm, n = 125), large abscess (5 cm to 10 cm, n = 218) and giant abscess (>10 cm, n = 36). The most common bacteria were Klebsiella pneumonia (22%) and Escherichia coli (11%) by pus culture, and Escherichia coli (36.7%), gram-positive coccus, (36.7%) and Klebsiella pneumonia (33.3%) by blood culture. 115 patients (28.0%) received antibiotics treatment alone, 161 patients (39.3%) received percutaneous drainage (PD) and 134 patients (32.7%) underwent surgical incision and drainage (SD). The size of abscess was correlated with leukocytes increase, albumin decrease, and time duration for body temperature normalization (all p  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep35890