Specific premature epigenetic aging of cartilage in osteoarthritis

Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2016-09, Vol.8 (9), p.2222-2231
Main Authors: Vidal-Bralo, Laura, Lopez-Golan, Yolanda, Mera-Varela, Antonio, Rego-Perez, Ignacio, Horvath, Steve, Zhang, Yuhua, Del Real, Álvaro, Zhai, Guangju, Blanco, Francisco J, Riancho, Jose A, Gomez-Reino, Juan J, Gonzalez, Antonio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging, Premature
Cartilage - pathology
Epigenesis, Genetic
Female
Humans
Male
Middle Aged
Osteoarthritis - genetics
Osteoarthritis - pathology
Research Paper
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Summary:Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age-measures (DmAM) were used: the multi-tissue age estimator for cartilage and bone; and a blood-specific biomarker for blood. Differences in DmAM between OA patients and controls showed an accelerated aging of 3.7 years in articular cartilage (95% CI = 1.1 to 6.3, = 0.008) of OA patients. By contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95% CI = -1.8 to 1.9, = 0.3) and in blood (-0.6 years; 95% CI = -1.5 to 0.3, = 0.2) between OA patients and controls. Therefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101053