HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer

The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cance...

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Bibliographic Details
Published in:Oncotarget 2016-05, Vol.7 (22), p.32754-32764
Main Authors: He, Junyi, Shen, Sheng, Lu, Weiqi, Zhou, Yuhong, Hou, Yingyong, Zhang, Yong, Jiang, Ying, Liu, Houbao, Shao, Yebo
Format: Article
Language:English
Subjects:
Animals
Basic Helix-Loop-Helix Transcription Factors - genetics
Basic Helix-Loop-Helix Transcription Factors - metabolism
Biomarkers, Tumor - metabolism
Cell Line, Tumor
Cell Movement
Epithelial-Mesenchymal Transition
Gallbladder Neoplasms - enzymology
Gallbladder Neoplasms - genetics
Gallbladder Neoplasms - mortality
Gallbladder Neoplasms - pathology
HEK293 Cells
Histone Deacetylase 1 - genetics
Histone Deacetylase 1 - metabolism
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Male
Mice, Nude
Neoplasm Invasiveness
Protein Binding
Research Paper
RNA Interference
Signal Transduction
Time Factors
Transfection
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Summary:The identification of prognostic markers for gallbladder cancer is needed for clinical practice. Histone deacetylases (HDACs) play an important role in tumor development and progression by modifying histone and non-histone proteins. However, the expression of HDAC1 in patients with gallbladder cancer is still unknown. Here, we reported that HDAC1 expression was elevated in cancerous tissue and correlated with lymph node metastasis and poorer overall survival in patients with GBC. Knockdown of HDAC1 using lentivirus delivery of HDAC1-specific shRNA abrogated the migration and invasion of GBC cells in vitro. TCF-12, as the HDAC1 binding protein, has also correlates with poor prognosis in GBC patients. And there is a positive correlation between HDAC1 and TCF-12 which leading the high invasion and migration ability of GBC cells. Taken together, our data suggested that HDAC1 and TCF-12 are a potential prognostic maker and may be a molecular target for inhibiting invasion and metastasis in GBC.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.8740