Third Trimester Brain Growth in Preterm Infants Compared With In Utero Healthy Fetuses

Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural brain injury. However, details regarding the onset and progression of impaired preterm brain development over the third trimester are unknown. Our primary objective w...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2016-11, Vol.138 (5), p.e20161640
Main Authors: Bouyssi-Kobar, Marine, du Plessis, Adré J, McCarter, Robert, Brossard-Racine, Marie, Murnick, Jonathan, Tinkleman, Laura, Robertson, Richard L, Limperopoulos, Catherine
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Brain - growth & development
Cohort Studies
Female
Fetal Development - physiology
Gestational Age
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Organ Size
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Third
Premature Birth - diagnostic imaging
Prenatal Diagnosis - methods
Prospective Studies
Reference Values
Risk Assessment
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Summary:Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural brain injury. However, details regarding the onset and progression of impaired preterm brain development over the third trimester are unknown. Our primary objective was to compare third-trimester brain volumes and brain growth trajectories in ex utero preterm infants without structural brain injury and in healthy in utero fetuses. As a secondary objective, we examined risk factors associated with brain volumes in preterm infants over the third-trimester postconception. Preterm infants born before 32 weeks of gestational age (GA) and weighing
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2016-1640