The relationship of systemic markers of renal function and vascular function with retinal blood vessel responses

Purpose To test the hypothesis of a significant relationship between systemic markers of renal and vascular function (processes linked to cardiovascular disease and its development) and retinal microvascular function in diabetes and/or cardiovascular disease. Methods Ocular microcirculatory function...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2016-11, Vol.254 (11), p.2257-2265
Main Authors: Heitmar, R., Varma, C., De, P., Lau, Y. C., Blann, A. D.
Format: Article
Language:English
Subjects:
Biomarkers - metabolism
Blood Pressure - physiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Creatinine - metabolism
Diabetes Mellitus - blood
Diabetes Mellitus - physiopathology
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Glomerular Filtration Rate - physiology
Glycated Hemoglobin A - metabolism
Humans
Kidney - physiopathology
Male
Medicine
Medicine & Public Health
Microcirculation - physiology
Middle Aged
Ophthalmology
Pathology
Photic Stimulation
Retinal Vessels - physiopathology
Vasodilation - physiology
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Summary:Purpose To test the hypothesis of a significant relationship between systemic markers of renal and vascular function (processes linked to cardiovascular disease and its development) and retinal microvascular function in diabetes and/or cardiovascular disease. Methods Ocular microcirculatory function was measured in 116 patients with diabetes and/or cardiovascular disease using static and continuous retinal vessel responses to three cycles of flickering light. Endothelial function was evaluated by von Willebrand factor (vWf), endothelial microparticles and soluble E selectin, renal function by serum creatinine, creatinine clearance and estimated glomerular filtration rate (eGFR). HbA1c was used as a control index. Results Central retinal vein equivalence and venous maximum dilation to flicker were linked to HbA1c (both p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-016-3432-9