Increased left ventricular myocardial extracellular volume is associated with longer cardiopulmonary bypass times, biventricular enlargement and reduced exercise tolerance in children after repair of Tetralogy of Fallot

Unfavorable left ventricular (LV) remodelling may be associated with adverse outcomes after Tetralogy of Fallot (TOF) repair. We sought to assess T1 cardiovascular magnetic resonance (CMR) markers of diffuse LV myocardial fibrosis in children after TOF repair, and associated factors. In this prospec...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular magnetic resonance 2016-10, Vol.18 (1), p.75-75, Article 75
Main Authors: Riesenkampff, Eugénie, Luining, Wietske, Seed, Mike, Chungsomprasong, Paweena, Manlhiot, Cedric, Elders, Bernadette, McCrindle, Brian W, Yoo, Shi-Joon, Grosse-Wortmann, Lars
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Cardiac Surgical Procedures - adverse effects
Cardiopulmonary bypass
Cardiopulmonary Bypass - adverse effects
Care and treatment
Case-Control Studies
Child
Cross-Sectional Studies
Diagnosis
Exercise Tolerance
Female
Fibrosis
Heart Ventricles - diagnostic imaging
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Heart Ventricles - surgery
Humans
Magnetic Resonance Imaging
Male
Operative Time
Prospective Studies
Risk Factors
Sex Factors
Stroke Volume
Tetralogy of Fallot
Tetralogy of Fallot - diagnostic imaging
Tetralogy of Fallot - physiopathology
Tetralogy of Fallot - surgery
Time Factors
Treatment Outcome
Ventricular Function, Left
Ventricular Remodeling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Unfavorable left ventricular (LV) remodelling may be associated with adverse outcomes after Tetralogy of Fallot (TOF) repair. We sought to assess T1 cardiovascular magnetic resonance (CMR) markers of diffuse LV myocardial fibrosis in children after TOF repair, and associated factors. In this prospective, cross-sectional study, native (=non-contrast) T1 times and extracellular volume fraction (ECV) were quantified in the LV myocardium using CMR. Results were related to ventricular volumes and function, degree of pulmonary regurgitation, as well as surgical characteristics, and exercise capacity. There was no difference in native T1 times or ECV between 31 TOF patients (age at CMR 13.9 ± 2.4 years, 19 male) and 15 controls (age at CMR 13.4 ± 2.6 years, 7 male). Female TOF patients had higher ECVs than males (25.2 ± 2.9 % versus 22.7 ± 3.3 %, p 
ISSN:1097-6647
1532-429X
DOI:10.1186/s12968-016-0290-x