Copper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters

The oxidative copper‐catalyzed cross‐coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, includ...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2016-10, Vol.22 (44), p.15654-15658
Main Authors: Mori-Quiroz, Luis M., Shimkin, Kirk W., Rezazadeh, Sina, Kozlowski, Ryan A., Watson, Donald A.
Format: Article
Language:English
Subjects:
alkyl boronic esters
Amides
Chemistry
copper
Coupling
Cross coupling
Esters
Ligands
NacNac ligand
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The oxidative copper‐catalyzed cross‐coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, including acetamide, have been developed. NacNac time! The oxidative copper‐catalyzed cross‐coupling of functionalized alkyl boronic esters with primary amides is reported. Through the identification of appropriate diketimine ligands, conditions for efficient coupling of both primary and secondary alkyl boronic esters with diverse primary amides, including acetamide, have been developed (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201603677