Animal models of excessive alcohol consumption: Recent advances and future challenges

[...]when given the opportunity to voluntarily drink alcohol, even under circumstances when access is unlimited, rodents rarely will consume alcohol in a manner that results in significant elevation in blood alcohol levels (above legal limits). [...]a major challenge for the field has been to overco...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2014-05, Vol.48 (3), p.205-208
Main Authors: Becker, Howard C, Ron, Dorit
Format: Article
Language:English
Subjects:
Alcohol Drinking
Alcohol use
Alcoholism
Alcoholism - complications
Alcoholism - genetics
Animals
Behavior
College students
Consumption
Genetic engineering
Models, Animal
Psychiatry
Rodents
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Summary:[...]when given the opportunity to voluntarily drink alcohol, even under circumstances when access is unlimited, rodents rarely will consume alcohol in a manner that results in significant elevation in blood alcohol levels (above legal limits). [...]a major challenge for the field has been to overcome these critical problems so that animal models developed for studying alcohol consumption have greater clinical relevance and, thereby, greater potential for use in both elucidating underlying mechanisms and identifying new and more effective treatment approaches. [...]while no single animal model can fully capture all the complexities of what drives humans to engage in excessive alcohol drinking behavior, collectively these models provide the field with valuable tools to address this important research question.
ISSN:0741-8329
1873-6823
1873-6823
DOI:10.1016/j.alcohol.2014.04.001