Level 5 Lymphadenopathy Warrants Heightened Suspicion for Clinically Significant Pathology

We conclude that patients presenting with level 5 lymphadenopathy should be investigated with heightened clinical vigilance. Our results suggest that up to 80 % will harbour clinically significant pathology requiring further medical treatment, three quarters of which will be malignancy. We report an...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2016-12, Vol.10 (4), p.509-512
Main Authors: Cunnane, M., Cheung, L., Moore, A., di Palma, S., McCombe, A., Pitkin, L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Dentistry
Female
Humans
Lymphadenopathy - etiology
Lymphadenopathy - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasms - pathology
Oral and Maxillofacial Surgery
Original Paper
Otorhinolaryngology
Pathology
Retrospective Studies
Young Adult
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Summary:We conclude that patients presenting with level 5 lymphadenopathy should be investigated with heightened clinical vigilance. Our results suggest that up to 80 % will harbour clinically significant pathology requiring further medical treatment, three quarters of which will be malignancy. We report an observational study of histological outcomes of level 5 lymph node biopsies from a regional histopathology department across 5 years. 184 subjects were identified as having a biopsy of a lymph node from the level 5 region within the study period. One hundred and fifty six cases (84.8 %) had clinically significant pathology on final histology requiring further medical treatment. Lymphoma accounted for the highest number of cases (n = 72, 39.1 %), followed by metastatic carcinoma (n = 65, 35.3 %) and granulomatous change (n = 17, 9.2 %). Gender and laterality were not shown to be independent predictors of pathology significance ( p  > 0.05).
ISSN:1936-055X
1936-0568
DOI:10.1007/s12105-016-0733-6