Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease

BACKGROUND AND PURPOSE—Abnormalities of the retinal circulation may be associated with cerebrovascular disease. We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic pop...

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Published in:Stroke (1970) 2016-11, Vol.47 (11), p.2862-2864
Main Authors: Hughes, Alun D, Falaschetti, Emanuela, Witt, Nicholas, Wijetunge, Sumangali, Thom, Simon A McG, Tillin, Therese, Aldington, Steve J, Chaturvedi, Nish
Format: Article
Language:English
Subjects:
Aged
Arterioles - diagnostic imaging
Cerebral Infarction - diagnostic imaging
Cerebral Infarction - epidemiology
Comorbidity
Female
Humans
Leukoaraiosis - diagnostic imaging
Leukoaraiosis - epidemiology
Magnetic Resonance Imaging
Male
Middle Aged
Retinal Diseases - diagnostic imaging
Retinal Diseases - epidemiology
Retinal Vessels - diagnostic imaging
Stroke - diagnostic imaging
Stroke - epidemiology
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cited_by cdi_FETCH-LOGICAL-c4530-c0935e05fffe91cef6c48a62f5b8fc60ae2ef0116a6e8a7d8da92b37486727573
cites cdi_FETCH-LOGICAL-c4530-c0935e05fffe91cef6c48a62f5b8fc60ae2ef0116a6e8a7d8da92b37486727573
container_end_page 2864
container_issue 11
container_start_page 2862
container_title Stroke (1970)
container_volume 47
creator Hughes, Alun D
Falaschetti, Emanuela
Witt, Nicholas
Wijetunge, Sumangali
Thom, Simon A McG
Tillin, Therese
Aldington, Steve J
Chaturvedi, Nish
description BACKGROUND AND PURPOSE—Abnormalities of the retinal circulation may be associated with cerebrovascular disease. We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic population-based cohort. METHODS—A total of 1185 participants (age, 68.8±6.1 years; 77% men) underwent retinal imaging and cerebral magnetic resonance imaging. Cerebral infarcts and white matter hyperintensities were identified on magnetic resonance imaging, retinopathy was graded, and retinal vessels were measured. RESULTS—Higher retinopathy grade (odds ratio [OR], 1.40 [95% confidence interval (95% CI), 1.16–1.70]), narrower arteriolar diameter (OR, 0.98 [95% CI, 0.97–0.99]), fewer symmetrical arteriolar bifurcations (OR, 0.84 [95% CI, 0.75–0.95]), higher arteriolar optimality deviation (OR, 1.16 [95% CI, 1.00–1.34]), and more tortuous venules (OR, 1.20 [95% CI, 1.09–1.32]) were associated with strokes/infarcts and white matter hyperintensities. Associations with quantitative retinal microvascular measures were independent of retinopathy. CONCLUSIONS—Abnormalities of the retinal microvasculature are independently associated with stroke, cerebral infarcts, and white matter lesions.
doi_str_mv 10.1161/STROKEAHA.116.014998
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We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic population-based cohort. METHODS—A total of 1185 participants (age, 68.8±6.1 years; 77% men) underwent retinal imaging and cerebral magnetic resonance imaging. Cerebral infarcts and white matter hyperintensities were identified on magnetic resonance imaging, retinopathy was graded, and retinal vessels were measured. RESULTS—Higher retinopathy grade (odds ratio [OR], 1.40 [95% confidence interval (95% CI), 1.16–1.70]), narrower arteriolar diameter (OR, 0.98 [95% CI, 0.97–0.99]), fewer symmetrical arteriolar bifurcations (OR, 0.84 [95% CI, 0.75–0.95]), higher arteriolar optimality deviation (OR, 1.16 [95% CI, 1.00–1.34]), and more tortuous venules (OR, 1.20 [95% CI, 1.09–1.32]) were associated with strokes/infarcts and white matter hyperintensities. Associations with quantitative retinal microvascular measures were independent of retinopathy. CONCLUSIONS—Abnormalities of the retinal microvasculature are independently associated with stroke, cerebral infarcts, and white matter lesions.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.116.014998</identifier><identifier>PMID: 27729577</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Aged ; Arterioles - diagnostic imaging ; Cerebral Infarction - diagnostic imaging ; Cerebral Infarction - epidemiology ; Comorbidity ; Female ; Humans ; Leukoaraiosis - diagnostic imaging ; Leukoaraiosis - epidemiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Retinal Diseases - diagnostic imaging ; Retinal Diseases - epidemiology ; Retinal Vessels - diagnostic imaging ; Stroke - diagnostic imaging ; Stroke - epidemiology</subject><ispartof>Stroke (1970), 2016-11, Vol.47 (11), p.2862-2864</ispartof><rights>2016 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4530-c0935e05fffe91cef6c48a62f5b8fc60ae2ef0116a6e8a7d8da92b37486727573</citedby><cites>FETCH-LOGICAL-c4530-c0935e05fffe91cef6c48a62f5b8fc60ae2ef0116a6e8a7d8da92b37486727573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27729577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hughes, Alun D</creatorcontrib><creatorcontrib>Falaschetti, Emanuela</creatorcontrib><creatorcontrib>Witt, Nicholas</creatorcontrib><creatorcontrib>Wijetunge, Sumangali</creatorcontrib><creatorcontrib>Thom, Simon A McG</creatorcontrib><creatorcontrib>Tillin, Therese</creatorcontrib><creatorcontrib>Aldington, Steve J</creatorcontrib><creatorcontrib>Chaturvedi, Nish</creatorcontrib><title>Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Abnormalities of the retinal circulation may be associated with cerebrovascular disease. We investigated associations between retinal microvascular abnormalities and (1) strokes and subclinical cerebral infarcts and (2) cerebral white matter lesions in a UK-based triethnic population-based cohort. METHODS—A total of 1185 participants (age, 68.8±6.1 years; 77% men) underwent retinal imaging and cerebral magnetic resonance imaging. Cerebral infarcts and white matter hyperintensities were identified on magnetic resonance imaging, retinopathy was graded, and retinal vessels were measured. RESULTS—Higher retinopathy grade (odds ratio [OR], 1.40 [95% confidence interval (95% CI), 1.16–1.70]), narrower arteriolar diameter (OR, 0.98 [95% CI, 0.97–0.99]), fewer symmetrical arteriolar bifurcations (OR, 0.84 [95% CI, 0.75–0.95]), higher arteriolar optimality deviation (OR, 1.16 [95% CI, 1.00–1.34]), and more tortuous venules (OR, 1.20 [95% CI, 1.09–1.32]) were associated with strokes/infarcts and white matter hyperintensities. Associations with quantitative retinal microvascular measures were independent of retinopathy. CONCLUSIONS—Abnormalities of the retinal microvasculature are independently associated with stroke, cerebral infarcts, and white matter lesions.</description><subject>Aged</subject><subject>Arterioles - diagnostic imaging</subject><subject>Cerebral Infarction - diagnostic imaging</subject><subject>Cerebral Infarction - epidemiology</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Leukoaraiosis - diagnostic imaging</subject><subject>Leukoaraiosis - epidemiology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retinal Diseases - diagnostic imaging</subject><subject>Retinal Diseases - epidemiology</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - epidemiology</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAUtBCILoV_gFCOXFL8EcfOBSlaCq0oqtQWcbQc7zNx6423ttOq_75etizlYFmjNzPvYxB6T_ARIS35dHl1cf79uD_pt_AIk6br5Au0IJw2ddNS-RItMGZdTUvhAL1J6RpjTJnkr9EBFYJ2XIgFuu5TCsbp7MJUBVtdQHZT2Og8PlR6Wu2w9tUPZ2K408nMXseqH6YQ19q77CBVv1weq8scww380SwhwvCM_cUl0AneoldW-wTvnv5D9PPr8dXypD47_3a67M9q03CGa4M7xgFzay10xIBtTSN1Sy0fpDUt1kDB4rKzbkFqsZIr3dGBiUa2ggou2CH6vPPdzMMaVgamHLVXm-jWOj6ooJ36vzK5Uf0Od4pjSQXDxeDjk0EMtzOkrNYuGfBeTxDmpIhknEnc8K5Qmx21XCelCHbfhmC1jUntY9pCtYupyD48H3Ev-pvLP9_74DPEdOPne4hqBO3zqEqQWLQC1xSXFqSgurwy-SOkUaHc</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Hughes, Alun D</creator><creator>Falaschetti, Emanuela</creator><creator>Witt, Nicholas</creator><creator>Wijetunge, Sumangali</creator><creator>Thom, Simon A McG</creator><creator>Tillin, Therese</creator><creator>Aldington, Steve J</creator><creator>Chaturvedi, Nish</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201611</creationdate><title>Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease</title><author>Hughes, Alun D ; 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identifier ISSN: 0039-2499
ispartof Stroke (1970), 2016-11, Vol.47 (11), p.2862-2864
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source Alma/SFX Local Collection
subjects Aged
Arterioles - diagnostic imaging
Cerebral Infarction - diagnostic imaging
Cerebral Infarction - epidemiology
Comorbidity
Female
Humans
Leukoaraiosis - diagnostic imaging
Leukoaraiosis - epidemiology
Magnetic Resonance Imaging
Male
Middle Aged
Retinal Diseases - diagnostic imaging
Retinal Diseases - epidemiology
Retinal Vessels - diagnostic imaging
Stroke - diagnostic imaging
Stroke - epidemiology
title Association of Retinopathy and Retinal Microvascular Abnormalities With Stroke and Cerebrovascular Disease
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